5-氯-3-(2-甲基苯基)-1,2-恶唑 | 192432-80-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氯-3-(2-甲基苯基)-1,2-恶唑
• 英文名称: 5-Chloro-3-(2-methylphenyl)-1,2-oxazole
• CAS: 192432-80-7
• 化学式: C₁₀H₈ClNO
• 分子量: 193.633
• InChiKey: ZBBHHRZRHNLBFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-氯-3-(2-甲基苯基)-1,2-恶唑 、 (3-Azepan-1-yl-propyl)-benzo[1,3]dioxol-5-ylmethyl-amine 在 正丁基锂 作用下， 以 乙醚 为溶剂， 生成 (3-Azepan-1-yl-propyl)-benzo[1,3]dioxol-5-ylmethyl-(3-o-tolyl-isoxazol-5-yl)-amine
  参考文献：
  名称：

  Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)

  摘要：

  The synthesis and biological evaluation of a series of nonpeptidic small molecule antagonists of the human platelet thrombin receptor (PAR-1) are described. Optimization of the 5-amino-3-arylisoxazole lead resulted in an approximate 100-fold increase in potency. The most potent of these compounds (54) inhibits platelet activation with IC50S of 90 nM against the thrombin receptor agonist peptide (TRAP) and 510 nM against thrombin as the agonist. Further, antagonist 54 fully blocks platelet aggregation stimulated by 1 nM thrombin for 10 min. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00745-4
• 作为产物：
  描述：

  3-(2-甲基苯基)-4H-1,2-恶唑-5-酮 在 三氯氧磷 作用下， 生成 5-氯-3-(2-甲基苯基)-1,2-恶唑
  参考文献：
  名称：

  Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)

  摘要：

  The synthesis and biological evaluation of a series of nonpeptidic small molecule antagonists of the human platelet thrombin receptor (PAR-1) are described. Optimization of the 5-amino-3-arylisoxazole lead resulted in an approximate 100-fold increase in potency. The most potent of these compounds (54) inhibits platelet activation with IC50S of 90 nM against the thrombin receptor agonist peptide (TRAP) and 510 nM against thrombin as the agonist. Further, antagonist 54 fully blocks platelet aggregation stimulated by 1 nM thrombin for 10 min. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00745-4

文献信息

• Reaction of Halogenated Cyclopropanes and Nitrosyl Cation:  Preparation of Isoxazoles
  作者：Shaw-Tao Lin、Shing-Huey Kuo、Fu-May Yang

  DOI：10.1021/jo962297i

  日期：1997.7.1
• Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)
  作者：Philippe G Nantermet、James C Barrow、George F Lundell、Janetta M Pellicore、Kenneth E Rittle、MaryBeth Young、Roger M Freidinger、Thomas M Connolly、Cindra Condra、Jerzy Karczewski、Rodney A Bednar、Stanley L Gaul、Robert J Gould、Kris Prendergast、Harold G Selnick

  DOI：10.1016/s0960-894x(01)00745-4

  日期：2002.2

  The synthesis and biological evaluation of a series of nonpeptidic small molecule antagonists of the human platelet thrombin receptor (PAR-1) are described. Optimization of the 5-amino-3-arylisoxazole lead resulted in an approximate 100-fold increase in potency. The most potent of these compounds (54) inhibits platelet activation with IC50S of 90 nM against the thrombin receptor agonist peptide (TRAP) and 510 nM against thrombin as the agonist. Further, antagonist 54 fully blocks platelet aggregation stimulated by 1 nM thrombin for 10 min. (C) 2002 Published by Elsevier Science Ltd.