8,11,14,17-eicosatetraenoic acid | 2091-26-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8,11,14,17-eicosatetraenoic acid
• 英文别名: 8, 11, 14, 17-Icosatetraenoic acid；(8E,11E,14E,17E)-icosa-8,11,14,17-tetraenoic acid
• CAS: 2091-26-1
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: HQPCSDADVLFHHO-GFRMADBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8,11,14,17-eicosatetraenoic acid 生成 -3 Arachidonic Acid methyl ester
  参考文献：
  名称：

  ROHWEDDER, WILLIAM K.;DUVAL, SANDRA M.;WOLF, DARHAL J.;EMKEN, EDWARD A., LIPIDS., 25,(1990) N, C. 401-405

  摘要：

  DOI：
• 作为产物：
  描述：

  EPA 生成 8,11,14,17-eicosatetraenoic acid
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• BIOPASSIVATING MEMBRANE STABILIZATION BY MEANS OF NITROCARBOXYLIC ACID-CONTAINING PHOSPHOLIPIDS IN PREPARATIONS AND COATINGS
  申请人：Dietz Ulrich

  公开号：US20140099354A1

  公开（公告）日：2014-04-10

  The present invention relates to nitro-carboxylic acid (s)-containing phospholipids, to be used for coating of medical devices such as stents, catheter balloons, wound pads or surgical suture material and for bio-passivating compositions, such as rinses, waterproofing solutions, coating solutions, cryoprotection solutions, cold preservation media, lyoprotection solutions, contrast media solutions, preservation and reperfusion solutions containing these compounds as well as preparing solutions thereof and coating medical devices as well as their uses.

  本发明涉及一种含硝基羧酸（s）的磷脂，用于涂覆医疗器械，如支架、导管球囊、伤口垫或外科缝合材料，以及用于生物钝化组合物，如漱口液、防水溶液、涂层溶液、冷冻保护溶液、冷藏介质、冻干保护溶液、造影介质溶液、含有这些化合物的保存和再灌注溶液，以及制备这些溶液和涂覆医疗器械以及它们的用途。
• NSAID derivatives of omega-3 polyunsaturated acids as gamma secretase modulators
  申请人：Jiva Pharma, Inc.

  公开号：US10125078B1

  公开（公告）日：2018-11-13

  The present invention relates to the NSAID derivatives of omega-3 fatty acids as gamma secretase modulators and their use in treating Alzheimer's disease, hypertriglyceridemia, and cardiovascular disease by reducing triglycerides, and for use as anti-inflammatory agents.

  本发明涉及 NSAID 衍生物的ω-3脂肪酸作为γ-分泌酶调节剂，并其在治疗阿尔茨海默病、高甘油三酯血症和心血管疾病中的使用，通过降低甘油三酯的含量，并用作抗炎药。
• Compositions comprising reverse isomers of conjugated linoleic acid
  申请人：Saebo Asgeir

  公开号：US20050215641A1

  公开（公告）日：2005-09-29

  The present invention relates to the field of human and animal nutrition, and in particular to certain novel compositions of conjugated linoleic acids (CLA). In particular, the present invention relates to CLA compositions comprising the c10,t12, c10,c12, t9,c11 and c9,c11 isomers of conjugated linoleic acid.

  本发明涉及人类和动物营养领域，特别是某些新颖的共轭亚油酸（CLA）组合物。具体而言，本发明涉及包含共轭亚油酸的c10,t12、c10,c12、t9,c11和c9,c11异构体的CLA组合物。
• Statins of Omega-3 Polyunsaturated Acids for Treating Hypercholesterolemia
  申请人：Jiva Pharma, Inc.

  公开号：US20150322032A1

  公开（公告）日：2015-11-12

  The present invention relates to novel statin derivatives of omega-3 fatty acids, and their use in treating hypercholesterolemia, obesity, hypertriglyceridemia, cardiovascular diseases, and metabolic diseases, and Alzheimer's disease.

  本发明涉及新型ω-3脂肪酸的他汀衍生物，以及它们在治疗高胆固醇血症、肥胖、高甘油三酯血症、心血管疾病、代谢疾病和阿尔茨海默病中的应用。
• Omefibrates for Treating Dyslipidemia and Cardiovascular Disease
  申请人：Jiva Pharma, Inc.

  公开号：US20150344402A1

  公开（公告）日：2015-12-03

  The present invention relates to the fibric acid derivatives of omega-3 fatty acids and their use in treating Type2 diabetes, obesity, hypertriglyceridemia, cardiovascular diseases, metabolic syndrome, cancer, Alzheimer's disease; and their use for modulating activity of peroxisome proliferator-activated receptors (PPARs).

  本发明涉及ω-3脂肪酸的纤维酸衍生物及其在治疗2型糖尿病、肥胖症、高三酰甘油血症、心血管疾病、代谢综合征、癌症、阿尔茨海默病中的用途；以及它们用于调节过氧化物酶体增殖活化受体（PPARs）的活性。