15deoxy-delta-12,14-PGJ2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 15deoxy-delta-12,14-PGJ2
• 英文别名: (Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.4
• InChiKey: VHRUMKCAEVRUBK-WKELIDJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] TRPA1 MODULATORS<br/>[FR] MODULATEURS DE TRPA1
  申请人：ALGOMEDIX INC

  公开号：WO2015103060A1

  公开（公告）日：2015-07-09

  This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the compounds.

  这份披露涉及到多环杂芳化合物，这些化合物可用作TRPA1调节剂，以及包括这些化合物的用于治疗疼痛的组合物和方法。
• Nitrated Lipids and Methods of Making and Using Thereof
  申请人：Freeman A. Bruce

  公开号：US20070232579A1

  公开（公告）日：2007-10-04

  Described herein are nitrated lipids and methods of making and using the nitrated lipids.

  本文描述了硝化脂质及其制备和使用方法。
• Modulation of prostaglandin/cyclooxygenase metabolic pathways
  申请人：Hunter-Fleming Limited

  公开号：EP2147673A1

  公开（公告）日：2010-01-27

  A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus and its sequelae, ischemic vascular diseases, pain associated with inflammation, inflammatory skin conditions, spinal cord injury, peripheral neuropathy, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, as well as various types of cancer may be treated or prevented by the use of compounds as agents which selectively enhance production of 15-deoxy-prostaglandin J2. The compounds are 7-hydroxy steroids of formula (IV) or a salt or ester thereof: wherein R1 represents hydrogen or methyl and R2, R3 and R4 each independently represents an oxo, hydroxy, mercapto, hydrogen, halogen, alkoxy, aryloxy or acyl group.

  与环氧化酶活性和前列腺素合成代谢途径有关的各种疾病和失调，例如 2 型糖尿病及其后遗症、缺血性血管疾病、与炎症有关的疼痛、皮肤炎症、使用选择性地增强 15-脱氧前列腺素 J2 生成的化合物作为制剂，可以治疗或预防脊髓损伤、周围神经病变、多发性硬化症、炎症性肠病和类风湿性关节炎以及各种类型的癌症。这些化合物为式（IV）的 7-羟基类固醇或其盐或酯： 其中 R1 代表氢或甲基，R2、R3 和 R4 各自独立地代表氧代、羟基、巯基、氢、卤素、烷氧基、芳氧基或酰基。
• Methods and compositions for treatment of autism
  申请人：The Johns Hopkins University

  公开号：EP2859890A2

  公开（公告）日：2015-04-15

  Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder. More particularly, said methods and compositions utilise hydroxyurea.

  本文公开了治疗自闭症的方法和组合物。 本文公开了治疗自闭症谱系障碍的方法和组合物。 更具体地说，所述方法和组合物利用羟基脲。
• PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR CATARACT, MEDICINAL COMPOSITION FOR PREVENTING AND/OR TREATING CATARACT, USE OF PPAR ACTIVATOR FOR PRODUCING SAME, AND EYEDROPS
  申请人：University of Fukui

  公开号：EP3733203A1

  公开（公告）日：2020-11-04

  Provided are agents for prevention and therapeutic treatment of cataract that act by a different mechanism from conventional agents, and use of a PPAR activator for production of such agents. An agent for prevention and/or therapeutic treatment of cataract, containing a PPAR activator as an active ingredient, is used.

  本发明提供了预防和治疗白内障的药剂，其作用机理与传统药剂不同，还提供了使用 PPAR 激活剂生产此类药剂的方法。一种用于预防和/或治疗白内障的药剂含有 PPAR 激活剂作为活性成分。