(1S,2R,6R,8R,9R)-N-tert-butyl-10-(4-methoxyphenyl)-11-oxospiro[3,5,7,13-tetraoxa-10-azatricyclo[6.5.0.02,6]tridecane-4,1'-cyclohexane]-9-carboxamide | 1373392-15-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1S,2R,6R,8R,9R)-N-tert-butyl-10-(4-methoxyphenyl)-11-oxospiro[3,5,7,13-tetraoxa-10-azatricyclo[6.5.0.02,6]tridecane-4,1'-cyclohexane]-9-carboxamide
• CAS: 1373392-15-4
• 化学式: C₂₅H₃₄N₂O₇
• 分子量: 474.554
• InChiKey: ZJYPNIOUHLHEDK-ZFVIQDPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  异氰酸叔丁酯 、 2-[(3aR,5S,6S,6aR)-5-formylspiro[3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole-2,1'-cyclohexane]-6-yl]oxyacetic acid 、 甲氧苯胺 以 甲醇 为溶剂， 反应 13.0h， 以78%的产率得到(1S,2R,6R,8R,9R)-N-tert-butyl-10-(4-methoxyphenyl)-11-oxospiro[3,5,7,13-tetraoxa-10-azatricyclo[6.5.0.02,6]tridecane-4,1'-cyclohexane]-9-carboxamide
  参考文献：
  名称：

  A novel sugar based intramolecular Ugi 3CC for the N-alkyl-3-oxo-4-aryl-octahydrofuro[2,3-f][1,4]oxazepine-5-carboxamides

  摘要：

  An intramolecular Ugi reaction of 3-carboxy tethered sugar aldehyde with aryl amines and isocyanides has been accomplished to produce a novel class of carbohydrate derivatives, 3-oxo-4-aryl-octahydrofuro[2,3-f][1,4]oxazepine-5-carboxamides in good yields. The stereochemistry of the products was assigned by NMR studies. This is the first report on intramolecular Ugi reaction of 3-carboxy tethered sugar aldehyde, aryl amine, and isonitrile. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.02.048