N-Hydroxy-2-oxo-N'-p-tolyl-2H-chromene-4-carboxamidine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-Hydroxy-2-oxo-N'-p-tolyl-2H-chromene-4-carboxamidine
• 英文别名: N-hydroxy-N'-(4-methylphenyl)-2-oxochromene-4-carboximidamide
• 化学式: C₁₇H₁₄N₂O₃
• 分子量: 294.31
• InChiKey: QGWUMYFZHKRKFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  70.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-Hydroxy-2-oxo-N'-p-tolyl-2H-chromene-4-carboxamidine 在 吡啶 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以66%的产率得到4-(2-Oxo-3-p-tolyl-2,3-dihydro-2λ⁴-[1,2,3,5]oxathiadiazol-4-yl)-chromen-2-one
  参考文献：
  名称：

  Synthesis and biological evaluation of several coumarin-4-carboxamidoxime and 3-(coumarin-4-yl)-1,2,4-oxadiazole derivatives

  摘要：

  A series of novel coumarin-4-carboxamidoximes 6a-g and 3-(coumarin-4-yl)-1,2,4-oxadiazoles 9a-e were synthesized from coumarin-4-carboxaldehyde 1 via the intermediate coumarin-4-nitriloxide 4. These coumarin derivatives were isolated and characterized, and evaluated for their ability to inhibit trypsin, glucuronidase, and soybean lipoxygenase. The compounds were also tested for antioxidant activity, and as antiiflammatory agents in the rat carrageenin paw edema assay. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80030-5
• 作为产物：
  描述：

  乙烷,三氯氟- 、 2-oxo-2H-[1]benzopyran-4-carbonitrile N-oxide 以 乙醚 为溶剂， 反应 3.0h， 以76%的产率得到N-Hydroxy-2-oxo-N'-p-tolyl-2H-chromene-4-carboxamidine
  参考文献：
  名称：

  Synthesis and biological evaluation of several coumarin-4-carboxamidoxime and 3-(coumarin-4-yl)-1,2,4-oxadiazole derivatives

  摘要：

  A series of novel coumarin-4-carboxamidoximes 6a-g and 3-(coumarin-4-yl)-1,2,4-oxadiazoles 9a-e were synthesized from coumarin-4-carboxaldehyde 1 via the intermediate coumarin-4-nitriloxide 4. These coumarin derivatives were isolated and characterized, and evaluated for their ability to inhibit trypsin, glucuronidase, and soybean lipoxygenase. The compounds were also tested for antioxidant activity, and as antiiflammatory agents in the rat carrageenin paw edema assay. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80030-5

文献信息

• Synthesis and biological evaluation of several coumarin-4-carboxamidoxime and 3-(coumarin-4-yl)-1,2,4-oxadiazole derivatives
  作者：Demetrios N. Nicolaides、Konstantina C. Fylaktakidou、Konstantinos E. Litinas、Dimitra Hadjipavlou-Litina

  DOI：10.1016/s0223-5234(98)80030-5

  日期：1998.9

  A series of novel coumarin-4-carboxamidoximes 6a-g and 3-(coumarin-4-yl)-1,2,4-oxadiazoles 9a-e were synthesized from coumarin-4-carboxaldehyde 1 via the intermediate coumarin-4-nitriloxide 4. These coumarin derivatives were isolated and characterized, and evaluated for their ability to inhibit trypsin, glucuronidase, and soybean lipoxygenase. The compounds were also tested for antioxidant activity, and as antiiflammatory agents in the rat carrageenin paw edema assay. (C) Elsevier, Paris.