2-Amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioic acid | 16597-19-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioic acid
• 英文别名: (Z)-2-amino-3-[(Z)-3-oxoprop-1-enyl]but-2-enedioic acid
• CAS: 16597-19-6
• 化学式: C₇H₇NO₅
• 分子量: 185.13
• InChiKey: KACPVQQHDVBVFC-OIFXTYEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Tandem repeat DNA constructs producing proteins that attack plant pathogenic viruses, fungi, and bacteria by disrupting transcription factors essential for replication thereof in plants
  申请人：Fernandez-Pol, Sebastian

  公开号：EP2123762A2

  公开（公告）日：2009-11-25

  Methods and compositions related to treating, controlling or inhibiting Geminiviruses by reducing or inhibiting growth of Geminiviruses (GV) employing a compound having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 R2, R3 and R4 are selected from a group consisting of a carboxyl group, methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, secondary butyl group, tertiary butyl group, pentyl group, isopentyl group, neopentyl group, fluorine, chlorine, bromine, iodine, and hydrogen. The present invention provides several classes of antiviral compounds which can be used to inactivate or disintegrate geminiviruses, such as the African cassava mosaic geminiviruses (ACMV) and East Africa cassava mosaic geminiviruses (EACMGV), by attacking the [ Zn 2+]-[CCHC] zinc finger domain or a variation thereof, such domain being present in the viral nucleocapsid or other viral ZFPs. The novel antiviral agents were designed to be used in plants infected by pathogenic viruses.

  通过使用具有以下结构的化合物来减少或抑制革兰氏病毒（GV）的生长，从而治疗、控制或抑制革兰氏病毒的方法和组合物： 或其药学上可接受的盐，其中 R1 R2、R3 和 R4 选自由羧基、甲基、乙基、丙基、异丙基、丁基、异丁基、仲丁基、叔丁基、戊基、异戊基、新戊基、氟、氯、溴、碘和氢组成的组。本发明提供了几类抗病毒化合物，它们可以通过攻击[Zn 2+]-[CCHC] 锌指结构域或其变体（这种结构域存在于病毒核壳或其他病毒 ZFP 中）来灭活或分解 geminiviruses，如非洲木薯花叶病毒（ACMV）和东非木薯花叶病毒（EACMGV）。新型抗病毒制剂设计用于受病原病毒感染的植物。