4-((6-methylpyridin-3-yl)methoxy)pyridin-2(1H)-one | 1260240-53-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-((6-methylpyridin-3-yl)methoxy)pyridin-2(1H)-one
• 英文别名: 4-[(6-methylpyridin-3-yl)methoxy]-1H-pyridin-2-one
• CAS: 1260240-53-6
• 化学式: C₁₂H₁₂N₂O₂
• 分子量: 216.239
• InChiKey: WTIWDNPUKIXSJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-((6-methylpyridin-3-yl)methoxy)pyridin-2(1H)-one 、 tert-butyl 8-bromo-4,5-dihydro-1H-benzofuro[3,2-c]azepine-2(3H)-carboxylate 在 盐酸 、 ammonium hydroxide 、 caesium carbonate 作用下， 以 乙醚 、 氮气 、 甲苯 为溶剂， 生成 4-((6-Methylpyridin-3-yl)methoxy)-1-(2,3,4,5-tetrahydro-1H-benzofuro[3,2-c]azepin-8-yl)pyridin-2(1H)-one
  参考文献：
  名称：

  PYRIDO-/AZEPINO-BENZOFURAN AND PYRIDO-/AZEPINO-BENZOTHIOPHENE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

  摘要：

  新型MCH-1受体拮抗剂被披露。这些化合物用于治疗包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神障碍在内的各种疾病。制造这些化合物的方法也进行了描述。

  公开号：

  US20140163012A1
• 作为产物：
  描述：

  6-甲基-3-羟甲基吡啶 在 copper(l) iodide 甲酸 、 1,10-菲罗啉 、 ammonium acetate 、 caesium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 136.0h， 生成 4-((6-methylpyridin-3-yl)methoxy)pyridin-2(1H)-one
  参考文献：
  名称：

  AZINONE-SUBSTITUTED AZEPINO[b]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

  摘要：

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神疾病。本发明还描述了制备这些化合物的方法。

  公开号：

  US20110003793A1

文献信息

• AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
  申请人：GUZZO Peter R.

  公开号：US20110003737A1

  公开（公告）日：2011-01-06

  Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神障碍。本发明还描述了制备这些化合物的方法。
• TETRAHYDRO-AZACARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF
  申请人：SURMAN Matthew D.

  公开号：US20120157460A1

  公开（公告）日：2012-06-21

  The present invention relates to tetrahydro-azacarboline derivatives of formula (I): having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof.

  本发明涉及式(I)的四氢-吖啶咔啉衍生物，其具有如本文所述的取代基，这些取代基是黑素浓缩激素（MCH-1）受体拮抗剂。本发明还涉及包括这些化合物的药物组合物，以及其制备和使用方法。
• AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
  申请人：GUZZO Peter R.

  公开号：US20110003738A1

  公开（公告）日：2011-01-06

  Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神疾病。本发明还描述了制备这些化合物的方法。
• AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
  申请人：GUZZO Peter R.

  公开号：US20110003739A1

  公开（公告）日：2011-01-06

  Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神障碍。本发明还描述了制备这些化合物的方法。
• Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
  申请人：Guzzo Peter R.

  公开号：US08618299B2

  公开（公告）日：2013-12-31

  MCH-1 receptor antagonists are disclosed having the general formula These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

  本发明揭示了具有通式的MCH-1受体拮抗剂，这些化合物可用于治疗各种疾病，包括肥胖症、焦虑症、抑郁症、非酒精性脂肪肝病和精神障碍。本发明还描述了制备这些化合物的方法。