5,7-Bis-allyloxy-8-propionyl-4-propyl-chromen-2-one | 461695-37-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 5,7-Bis-allyloxy-8-propionyl-4-propyl-chromen-2-one
• 英文别名: 5,7-Diallyloxy-8-propanoyl-4-propyl-chromen-2-one；8-propanoyl-5,7-bis(prop-2-enoxy)-4-propylchromen-2-one
• CAS: 461695-37-4
• 化学式: C₂₁H₂₄O₅
• 分子量: 356.419
• InChiKey: RCJSMRYVPQNNRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,7-Bis-allyloxy-8-propionyl-4-propyl-chromen-2-one 在 sodium tetrahydroborate 、 氨 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 5,7-Bis-allyloxy-8-(1-amino-propyl)-4-propyl-chromen-2-one
  参考文献：
  名称：

  Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

  摘要：

  Pyranocoumarin compounds were identified to embody a novel and unique pharmacophore for anti-TB activity. A systematic approach was taken to investigate the structural characteristics. Focused libraries of compounds were synthesized and evaluated for their anti-TB activity in primary screening assays. Compounds shown to be active were further determined for MIC and MBC values. Three of the four bactericidal compounds (16, 17c, and 18f) were amino derivatives, with MIC values of 16 mu g/mL and respective MBC values of 32, 32, and 64 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.02.017
• 作为产物：
  描述：

  3-溴丙烯 、 5,7-二羟基-8-丙酰-4-丙基-2H-色烯-2-酮 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以80%的产率得到5,7-Bis-allyloxy-8-propionyl-4-propyl-chromen-2-one
  参考文献：
  名称：

  Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

  摘要：

  Pyranocoumarin compounds were identified to embody a novel and unique pharmacophore for anti-TB activity. A systematic approach was taken to investigate the structural characteristics. Focused libraries of compounds were synthesized and evaluated for their anti-TB activity in primary screening assays. Compounds shown to be active were further determined for MIC and MBC values. Three of the four bactericidal compounds (16, 17c, and 18f) were amino derivatives, with MIC values of 16 mu g/mL and respective MBC values of 32, 32, and 64 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.02.017