N,N-diethyl-2-(3-fluorophenyl)acetamide | 763102-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-2-(3-fluorophenyl)acetamide
• CAS: 763102-64-3
• 化学式: C₁₂H₁₆FNO
• mdl: MFCD20142417
• 分子量: 209.264
• InChiKey: SALQAZNQEFLJCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二乙胺 、 1-(bromoethynyl)-3-fluorobenzene 在 水 作用下， 反应 6.0h， 以92%的产率得到N,N-diethyl-2-(3-fluorophenyl)acetamide
  参考文献：
  名称：

  Practical synthesis of amides from alkynyl bromides, amines, and water

  摘要：

  A general and efficient method for the synthesis of a wide range of amides is described here. The reactions were conducted under convenient conditions and provided secondary and tertiary amides in moderate to excellent yields. A variety of amines and substituted alkynyl bromides were used to investigate the scope of the reactions. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.06.045

文献信息

• Practical synthesis of amides from alkynyl bromides, amines, and water
  作者：Zheng-Wang Chen、Huan-Feng Jiang、Xiao-Yan Pan、Zai-Jun He

  DOI：10.1016/j.tet.2011.06.045

  日期：2011.8

  A general and efficient method for the synthesis of a wide range of amides is described here. The reactions were conducted under convenient conditions and provided secondary and tertiary amides in moderate to excellent yields. A variety of amines and substituted alkynyl bromides were used to investigate the scope of the reactions. (C) 2011 Elsevier Ltd. All rights reserved.