胞嘧啶钠盐 | 55175-08-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 胞嘧啶钠盐
• 英文名称: sodium salt of cytosine
• 英文别名: cytosine sodium salt；Sodium;6-iminopyrimidin-3-id-2-one；sodium;6-iminopyrimidin-3-id-2-one
• CAS: 55175-08-1
• 化学式: C₄H₄N₃O*Na
• 分子量: 133.085
• InChiKey: JVLUYUNNSCKSOF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.01
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  碳酸乙烯酯 、 胞嘧啶钠盐 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.5h， 以66.2%的产率得到4-amino-1-(2-hydroxyethyl)pyrimidin-2-one
  参考文献：
  名称：

  Synthesis and binding properties of monomeric and dimeric guanine and cytosine amine derivatives

  摘要：

  The syntheses of the N-protected forms of the cytosine homodimer 1, the guanine cytosine heterodimer 2, and the guanine homodimer 3 are described. Derivatization of these dimers, as well as the protected monomers corresponding to 4 and 5, with omega-methoxypoly(ethylene glycol)-alpha-carboxylic acid 26 and subsequent deprotection formed the amides 29, 31, 33, 35, and 37. The binding properties of these solubilized compounds in DMSO-d(g) were examined using H-1 NMR.

  DOI：

  10.1021/jo00029a008

文献信息

• Synthesis of polyfluorene and oligofluorene with N 1 -hexylcytosine side chains and their sensing ability for nucleosides
  作者：Isao Yamaguchi、Koji Miyawaki

  DOI：10.1016/j.reactfunctpolym.2017.09.001

  日期：2017.11

  (PF) and oligofluorene (OF) with N1-hexylcytosine side chains were synthesized by Pd-complex-catalyzed condensation reactions starting from a newly synthesized monomer. The UV–vis spectra of the PF exhibit the absorption maximum at a longer wavelength than that of the OF, thus revealing that a π-conjugation system extends along the polymer chain. The PF and OF are photoluminescent in solution, and their

  摘要以钯为原料，通过Pd络合物催化的缩合反应合成了具有N1-己基胞嘧啶侧链的聚芴（PF）和低聚芴（OF）。PF的UV-vis光谱在比OF更长的波长处表现出最大吸收，因此揭示了π共轭体系沿着聚合物链延伸。PF和OF在溶液中是光致发光的，并且通过向溶液中添加核苷（例如腺苷，胞苷和鸟苷）来逐渐降低其光致发光（PL）强度。PL强度的降低很可能是由于PF和OF胞嘧啶基团在其侧链与核苷之间通过氢键键合产生的复合物中的光致电荷转移（PCT）从PF和OF的主链到核苷所致。在核苷中，鸟苷是最有效的PL淬灭剂。OF的循环伏安法（CV）分析表明它具有电化学活性。
• Synthesis of (t-2-benzyloxymethyl-t-3-hydroxy-r-1-methoxycarbonyl)-tetrahydrofuran from an arabino-lactone triflate with K₂CO₃–MeOH
  作者：Takao Izawa、Kumiko Nakayama、Shigeru Nishiyama、Shosuke Yamamura、Kuniki Kato、Tomohisa Takita

  DOI：10.1039/p19920003003

  日期：——

  The arabino-lactone triflate 4 reacts with K2CO3 in MeOH to give the oxetane ester 5 and the tetrahydrofuran ester 6 in a ratio dependent upon the reaction temperature.
• KIM, CHOUNG UN;MISCO, PETER F.;LUH, BING YU;HITCHCOCK, MICHAEL J. M.;GHAZ+, J. MED. CHEM., 34,(1991) N, C. 2286-2294
  作者：KIM, CHOUNG UN、MISCO, PETER F.、LUH, BING YU、HITCHCOCK, MICHAEL J. M.、GHAZ+

  DOI：——

  日期：——
• OVERBERGER, C. G.;CHANG, JI YOUNG, TETRAHEDRON LETT., 30,(1989) N 1, C. 51-54
  作者：OVERBERGER, C. G.、CHANG, JI YOUNG

  DOI：——

  日期：——