5-氯甲基-2-甲基-苯甲酸 | 66658-52-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氯甲基-2-甲基-苯甲酸
• 英文名称: 5-chloromethyl-2-methyl-benzoic acid
• 英文别名: 5-Chlormethyl-2-methyl-benzoesaeure；5-(chloromethyl)-2-methyl-benzoic acid；5-(Chloromethyl)-2-methylbenzoic acid
• CAS: 66658-52-4
• 化学式: C₉H₉ClO₂
• 分子量: 184.622
• InChiKey: UTLCUFLGDKUSRE-UHFFFAOYSA-N

物化性质

• 熔点：
  113-114 °C
• 沸点：
  333.3±30.0 °C(Predicted)
• 密度：
  1.265±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-氯甲基-2-甲基-苯甲酸 在 乙醇 、 溶剂黄146 、 锌 作用下， 生成 2,5-二甲基苯甲酸
  参考文献：
  名称：

  Rapid senescence induced by overexpression of p53 in NIH3T3 cells

  摘要：

  An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene, It exhibited rapidly characteristic morphological and biochemical alterations related to replicative senescence when being cultured in 32 degreesC. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.

  DOI：

  10.1007/bf03182827
• 作为产物：
  描述：

  5-chloromethyl-2-methyl-benzoyl chloride 在 硫酸 作用下， 生成 5-氯甲基-2-甲基-苯甲酸
  参考文献：
  名称：

  Rapid senescence induced by overexpression of p53 in NIH3T3 cells

  摘要：

  An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene, It exhibited rapidly characteristic morphological and biochemical alterations related to replicative senescence when being cultured in 32 degreesC. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.

  DOI：

  10.1007/bf03182827

文献信息

• [EN] PHENYL mTORC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE MTORC PHÉNYLE ET LEURS UTILISATIONS
  申请人：NAVITOR PHARM INC

  公开号：WO2018089433A1

  公开（公告）日：2018-05-17

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用相同的方法。
• US4182775A
  申请人：——

  公开号：US4182775A

  公开（公告）日：1980-01-08
• Rapid senescence induced by overexpression of p53 in NIH3T3 cells
  作者：Jiancheng Hu、Ying Lei、Xia Hong、Zhigang Lu、Zhonghe Zhai

  DOI：10.1007/bf03182827

  日期：2001.4

  An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene, It exhibited rapidly characteristic morphological and biochemical alterations related to replicative senescence when being cultured in 32 degreesC. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.