5-(benzyl(tert-butoxycarbonyl)amino)pentanoic acid methyl ester | 1392096-50-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(benzyl(tert-butoxycarbonyl)amino)pentanoic acid methyl ester
• 英文别名: Methyl 5-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoate
• CAS: 1392096-50-2
• 化学式: C₁₈H₂₇NO₄
• 分子量: 321.417
• InChiKey: VYRAEPCTEMCYLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-苄基-2-哌啶酮 在 盐酸 、 三乙胺 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 5-(benzyl(tert-butoxycarbonyl)amino)pentanoic acid methyl ester
  参考文献：
  名称：

  A one-pot selective synthesis of N-Boc protected secondary amines: tandem direct reductive amination/N-Boc protection

  摘要：

  A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)(2)O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.055

文献信息

• A one-pot selective synthesis of N-Boc protected secondary amines: tandem direct reductive amination/N-Boc protection
  作者：Raghupathi Neelarapu、Pavel A. Petukhov

  DOI：10.1016/j.tet.2012.06.055

  日期：2012.9

  A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)(2)O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization. (C) 2012 Elsevier Ltd. All rights reserved.