5-氯磺酰基苯-1,3-二羧酸 | 134178-04-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氯磺酰基苯-1,3-二羧酸
• 英文名称: 5-(chlorosulfonyl)isophthalic acid
• 英文别名: 5-Chlorosulfonylisophthalic acid；1,3-Benzenedicarboxylic acid, 5-(chlorosulfonyl)-；5-chlorosulfonylbenzene-1,3-dicarboxylic acid
• CAS: 134178-04-4
• 化学式: C₈H₅ClO₆S
• mdl: MFCD00090839
• 分子量: 264.643
• InChiKey: HPZPALJUGOSUMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2917399090

反应信息

• 作为反应物：
  描述：

  5-氯磺酰基苯-1,3-二羧酸 在 盐酸 、 锌 作用下， 以 乙醇 为溶剂， 以60%的产率得到5-巯基间苯二甲酸
  参考文献：
  名称：

  Evans, Brian J.; Doi, Joyce Takahashi; Musker, W. Kenneth, Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 73, # 1-4, p. 5 - 14

  摘要：

  DOI：
• 作为产物：
  描述：

  间苯二甲酸 在 氯磺酸 作用下， 以51 %的产率得到5-氯磺酰基苯-1,3-二羧酸
  参考文献：
  名称：

  Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease

  摘要：

  DOI：

  10.1016/j.bmcl.2022.129121

文献信息

• Aryl Bis-Sulfonamide Inhibitors of IspF from<i>Arabidopsis thaliana</i>and<i>Plasmodium falciparum</i>
  作者：Jonas Thelemann、Boris Illarionov、Konstantin Barylyuk、Julie Geist、Johannes Kirchmair、Petra Schneider、Lucile Anthore、Katharina Root、Nils Trapp、Adelbert Bacher、Matthias Witschel、Renato Zenobi、Markus Fischer、Gisbert Schneider、François Diederich

  DOI：10.1002/cmdc.201500382

  日期：2015.12

  4‐cyclodiphosphate synthase (IspF) is an essential enzyme for the biosynthesis of isoprenoid precursors in plants and many human pathogens. The protein is an attractive target for the development of anti‐infectives and herbicides. Using a photometric assay, a screen of 40 000 compounds on IspF from Arabidopsis thaliana afforded symmetrical aryl bis‐sulfonamides that inhibit IspF from A. thaliana (AtIspF)

  2-甲基赤藓糖醇2,4-环二磷酸合酶（IspF）是植物和许多人类病原体中类异戊二烯前体生物合成的必需酶。该蛋白是开发抗感染剂和除草剂的有吸引力的靶标。使用光度测定法，对拟南芥IspF上的40 000种化合物进行筛选，得到对称的芳基双磺酰胺，可抑制拟南芥（At IspF）和恶性疟原虫（Pf IspF）的IspF，IC 50值在微摩尔范围内。在邻-二磺酰胺结构基元是用于抑制活性至关重要。通过平行合成获得的最佳衍生物显示IC 50的1.4μ值米针对Pf的ISPF和240Ñ米针对在ISPF。在2kg ha -1的剂量下观察到大量除草活性。分子模型研究是针对新型非对称磺酰胺IspF抑制剂的发现进行计算机搜索的基​​础。发现设计的化合物在两位数的微摩尔IC 50范围内表现出抑制活性。
• Methods and articles of manufacture for the treatment of skin
  申请人：Advanced Collagen Science LLC

  公开号：US10888511B2

  公开（公告）日：2021-01-12

  Embodiments of the present invention are directed to methods and articles of manufacture to treat skin to improve and/or increase hydration, pliability, and thickness for improved texture, feel and appearance. Embodiments feature applying an effective amount of an acetylation agent to natural dermal collagen under reaction conditions to react the natural dermal collagen with the acetylation agent to form a modified collagen. The modified collagen has a higher net charge and higher net charge density than natural dermal collagen. The modified collagen improves or increases one or more skin characteristics consisting of hydration, pliability and thickness.

  本发明的实施例涉及治疗皮肤的方法和制造品，以改善和/或增加皮肤的水合作用、柔韧性和厚度，从而改善皮肤的质地、触感和外观。本发明实施例的特点是在反应条件下，将有效量的乙酰化剂用于天然真皮胶原蛋白，使天然真皮胶原蛋白与乙酰化剂反应，形成改性胶原蛋白。改性胶原蛋白比天然真皮胶原蛋白具有更高的净电荷和净电荷密度。改性胶原蛋白可改善或增加一种或多种皮肤特性，包括水合性、柔韧性和厚度。
• Device, dispensing apparatus and methods for administering collagen modifier compounds
  申请人：Advanced Collagen Science LLC

  公开号：US11331462B2

  公开（公告）日：2022-05-17

  Embodiments of the present invention are directed to devices and apparatus for administering collagen modifier compounds to the dermis of skin.

  本发明的实施方案涉及向皮肤真皮层施用胶原蛋白修饰化合物的装置和设备。
• Methods and apparatus for accelerated orthokeratology
  申请人：——

  公开号：US20010016731A1

  公开（公告）日：2001-08-23

  An accelerated method of orthokeratology includes the steps of softening of the cornea with a softening agent, applying a mold to reshape the cornea to a desired anterior curvature, and rapidly restabilizing or “fixing” the corneal tissues so that the cornea retains its new configuration. A chemical softening agent, such as glutaric anhydride is applied to the cornea to soften the cornea, after which a specially designed mold of predetermined curvature and configuration is applied to the cornea. Slight downward pressure is applied to the mold for a predetermined period of time to re-shape the cornea. The mold is maintained in position while a stabilizing agent, such as a UV light source, is positioned above the mold. The stabilizing agent, i.e. UV light, is applied to the cornea for a predetermined time, wherein the stabilizing agent immediately restabilizes the corneal tissue so that the cornea immediately retains its shape upon removal of the mold. The stabilization process can also be used for patients having already undergone traditional orthokeratology to eliminate the need to continue wearing a retainer to maintain the shape of the cornea.

  角膜矫形术的加速方法包括以下步骤：用软化剂软化角膜，使用模具将角膜重塑成所需的前弧度，并迅速重新稳定或 "固定 "角膜组织，使角膜保持新的形态。在角膜上涂抹化学软化剂（如戊二酸酐）以软化角膜，然后在角膜上涂抹专门设计的具有预定弧度和结构的模具。在预定时间内对模具施加轻微的向下压力，以重新塑形角膜。将稳定剂（如紫外线光源）置于模具上方时，模具将保持在原位。将稳定剂（即紫外线）照射到角膜上，持续预定的时间，其中稳定剂会立即重新稳定角膜组织，使角膜在移除模具后立即保持其形状。稳定过程也可用于已接受传统角膜矫形术的患者，使其无需继续佩戴保持器来保持角膜的形状。
• Chemical treatment of in vivo tissue to alter charge and net charge density characteristics
  申请人：Devore Paul Dale

  公开号：US20050106270A1

  公开（公告）日：2005-05-19

  A method for treating animal tissue with acylation agents to alter the net charge and net charge density of the treated tissue for therapeutic applications is provided. The method involves applying an alkaline solution to the exposed tissue surface area. This results in deprotonation of ε-amino groups of lysine residues on the exposed tissue proteins so that the tissue proteins have a net charge. Then, an acylating agent is applied and the acylating agent reacts with the tissue protein to form a protein complex having an altered net charge. Acylating agents such as sulfonic acids, sulfonyl chlorides, and acid chlorides can be used. The method can be used to treat a wide variety of human tissues including the human cornea for correcting myopia. The method can also be used to treat skin tissue, so that there is an increase in dermal thickness and pliability. The method can be further used to treat articular cartilage.

  本发明提供了一种用酰化剂处理动物组织的方法，以改变被处理组织的净电荷和净电荷密度，从而达到治疗目的。该方法包括在暴露的组织表面区域使用碱性溶液。这将导致暴露的组织蛋白质上赖氨酸残基的 ε- 氨基基团发生去质子化作用，从而使组织蛋白质带有净电荷。然后，使用酰化剂，酰化剂与组织蛋白反应，形成净电荷改变的蛋白复合物。可使用磺酸、磺酰氯和酸氯化物等酰化剂。该方法可用于治疗各种人体组织，包括用于矫正近视的人体角膜。该方法还可用于治疗皮肤组织，从而增加真皮厚度和柔韧性。该方法还可用于治疗关节软骨。