5-溴-1,3-苯二甲酰胺 | 160892-06-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-溴-1,3-苯二甲酰胺
• 中文别名: 5-溴苯-1,3-二甲酰胺；5-溴间苯二甲酰胺
• 英文名称: 5-bromo-1,3-benzenedicarboxamide
• 英文别名: 5-bromobenzene-1,3-dicarboxamide
• CAS: 160892-06-8
• 化学式: C₈H₇BrN₂O₂
• 分子量: 243.06
• InChiKey: DJXPGIBWWMREIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-溴-1,3-苯二甲酰胺 在 polyphosphate ester 、 sulfur 作用下， 以 氯仿 为溶剂， 反应 28.0h， 生成 2,2'-(5-bromo-1,3-phenylene)bis<4,5-dihydroimidazole>
  参考文献：
  名称：

  Doyle, Timothy J.; Haseltine, John, Journal of Heterocyclic Chemistry, 1994, vol. 31, # 6, p. 1417 - 1420

  摘要：

  DOI：
• 作为产物：
  描述：

  5-溴间苯二甲酰二氯 在 ammonium hydroxide 作用下， 生成 5-溴-1,3-苯二甲酰胺
  参考文献：
  名称：

  Doyle, Timothy J.; Haseltine, John, Journal of Heterocyclic Chemistry, 1994, vol. 31, # 6, p. 1417 - 1420

  摘要：

  DOI：

文献信息

• Inhibitors Of Beta-Secretase
  申请人：Dillard Lawrence W.

  公开号：US20110218192A1

  公开（公告）日：2011-09-08

  The present invention is directed to a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. Pharmaceutical composition comprising a compound represented by Structural Formula (I) and method of use of these compound for inhibiting BACE activity in a subject in need of such treatment are also described.

  本发明涉及以下结构式所表示的化合物或其药学上可接受的盐。还描述了包含由结构式（I）所表示的化合物的药物组合物和使用这些化合物抑制需要此类治疗的受体中的BACE活性的方法。
• INHIBITORS OF BETA-SECRETASE
  申请人：Dillard Lawrence W.

  公开号：US20130317014A1

  公开（公告）日：2013-11-28

  The present invention is directed to a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. Pharmaceutical composition comprising a compound represented by Structural Formula (I) and method of use of these compound for inhibiting BACE activity in a subject in need of such treatment are also described.

  本发明涉及以下结构式所代表的化合物：或其药学上可接受的盐。还描述了包括结构式（I）所代表的化合物的药物组合物以及使用这些化合物抑制需要此类治疗的受体中的BACE活性的方法。
• Organic electron transport material and organic electroluminescent element using same
  申请人：Dyden Corporation

  公开号：US11031561B2

  公开（公告）日：2021-06-08

  An organic electron transport material, which includes a phosphine oxide derivative represented by the following Formula (1): R1 represents an atomic group which has either or both of one or more aryl groups and one or more heteroaryl groups and which may have one or more phosphine oxide group, and R2 to R9 each independently represent an atom or an atomic group selected from the group consisting of a hydrogen atom, a halogen atom, a cyano group, a C1-C12 linear or branched alkyl group, a linear or branched fluoroalkyl group, an aryl group, a substituted aryl group, a heteroaryl group, and a substituted heteroaryl group.

  一种有机电子传输材料，其中包括由下式（1）表示的氧化膦衍生物： R1 代表一个原子团，该原子团具有一个或多个芳基和一个或多个杂芳基中的一个或两个，并可具有一个或多个氧化膦基团；R2 至 R9 各自独立地代表一个原子或原子团，该原子或原子团选自由氢原子、卤素原子、氰基、C1-C12 直链或支链烷基、直链或支链氟烷基、芳基、取代的芳基、杂芳基和取代的杂芳基组成的组。
• ORGANIC ELECTRON TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME
  申请人：Dyden Corporation

  公开号：US20200168807A1

  公开（公告）日：2020-05-28

  An organic electron transport material, which includes a phosphine oxide derivative represented by the following Formula (1): R 1 represents an atomic group which has either or both of one or more aryl groups and one or more heteroaryl groups and which may have one or more phosphine oxide group, and R 2 to R 9 each independently represent an atom or an atomic group selected from the group consisting of a hydrogen atom, a halogen atom, a cyano group, a C 1 -C 12 linear or branched alkyl group, a linear or branched fluoroalkyl group, an aryl group, a substituted aryl group, a heteroaryl group, and a substituted heteroaryl group.
• US8450308B2
  申请人：——

  公开号：US8450308B2

  公开（公告）日：2013-05-28