N,N-diethyl-5-nitrobenzo[b]selenophen-2-amine | 1427505-08-5

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: N,N-diethyl-5-nitrobenzo[b]selenophen-2-amine
• 英文别名: N,N-diethyl-5-nitro-1-benzo-selenophen-2-amine；N,N-diethyl-5-nitro-1-benzoselenophen-2-amine
• CAS: 1427505-08-5
• 化学式: C₁₂H₁₄N₂O₂Se
• 分子量: 297.215
• InChiKey: MGSAQDWRGVLHEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-5-硝基苯乙酮 在 selenium(IV) oxide 、 sodium acetate 、 potassium hydroxide 作用下， 以 水 、 溶剂黄146 、 异丙醇 为溶剂， 反应 10.0h， 生成 N,N-diethyl-5-nitrobenzo[b]selenophen-2-amine
  参考文献：
  名称：

  A Novel Synthesis of Benzo[b]selenophenes via Regioselective Intramolecular Transformation of 4-(3-Nitroaryl)-1,2,3-selenadiazoles

  摘要：

  Base-promoted transformation of 4-(3-nitroaryl)-1,2,3-selenadiazoles via intermediate formation of eneselenolates followed by 5-exo-trig cyclization Is reported. The regiochemistry of the intramolecular cyclization is condition-dependent. In the presence of an oxidant, the oxidative nucleophilic substitution of the hydrogen (ONSH, SNArH) pathway, by oxidative aromatization of the rapidly formed sigma(H)-adduct, takes place. In the absence of oxidant, the reaction proceeds via intermediate formation of the sigma(Cl)-adduct, following nucleophilic aromatic substitution of the halogen (SNArCl) pathway.

  DOI：

  10.1021/ol400547n

文献信息

• A convenient synthesis of benzo[b]chalcogenophenes from 4-(2-chloro-5-nitrophenyl)-1,2,3-chalcogenadiazoles
  作者：Anna G. Lyapunova、Dmitry A. Androsov、Mikhail L. Petrov

  DOI：10.1016/j.tetlet.2013.04.077

  日期：2013.6

  An unusual base-promoted transformation of readily available 4-(2-chloro-5-nitrophenyI)-1,2,3-thia-and selenadiazoles affords a convenient approach toward benzo[b]thiophenes and benzo[b]selenophenes. (C) 2013 Elsevier Ltd. All rights reserved.
• Novel transformation of 4-(nitroaryl)-1,2,3-selenadiazoles into 1-benzoselenophen-2-amines
  作者：M. L. Petrov、A. G. Lyapunova、D. A. Androsov

  DOI：10.1134/s107042801304026x

  日期：2013.4
• A Novel Synthesis of Benzo[<i>b</i>]selenophenes via Regioselective Intramolecular Transformation of 4-(3-Nitroaryl)-1,2,3-selenadiazoles
  作者：Anna G. Lyapunova、Mikhail L. Petrov、Dmitry A. Androsov

  DOI：10.1021/ol400547n

  日期：2013.4.5

  Base-promoted transformation of 4-(3-nitroaryl)-1,2,3-selenadiazoles via intermediate formation of eneselenolates followed by 5-exo-trig cyclization Is reported. The regiochemistry of the intramolecular cyclization is condition-dependent. In the presence of an oxidant, the oxidative nucleophilic substitution of the hydrogen (ONSH, SNArH) pathway, by oxidative aromatization of the rapidly formed sigma(H)-adduct, takes place. In the absence of oxidant, the reaction proceeds via intermediate formation of the sigma(Cl)-adduct, following nucleophilic aromatic substitution of the halogen (SNArCl) pathway.