5-溴-2,2-二氟戊酸 | 61427-29-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 5-溴-2,2-二氟戊酸
• 英文名称: 2,2-difluoro-5-bromo-pentanoic acid
• 英文别名: 5-Bromo-2,2-difluoropentanoic acid
• CAS: 61427-29-0
• 化学式: C₅H₇BrF₂O₂
• 分子量: 217.01
• InChiKey: FVJPOVMWLWMZHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-溴-2,2-二氟戊酸 、 三苯基膦 生成 5-[Bromo(triphenyl)-lambda5-phosphanyl]-2,2-difluoropentanoic acid
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl-2,2-difluoro-5-bromo-pentanoate 生成 5-溴-2,2-二氟戊酸
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• 7-oxabicycloheptane substituted amide-carbamate prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04652576A1

  公开（公告）日：1987-03-24

  7-Oxabicycloheptane substituted amide-carbamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.3 and R.sup.4 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.3 and R.sup.4 being other than hydroxy and lower alkoxy; p is 1 to 5; R.sup.1 is H or lower alkyl; q is 1 to 12; and R.sup.2 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, or arylalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  7-氧代双环庚烷取代酰胺-尿素前列腺素类似物具有结构式##STR1##其中m为0至4；A为--CH.dbd.CH--或--CH.sub.2 --CH.sub.2 --；n为1至5；Q为--CH.dbd.CH--，--CH.sub.2 --，##STR2##或单键；R为CO.sub.2 H，CO.sub.2烷基，CO.sub.2碱金属，CO.sub.2多羟胺盐，--CH.sub.2 OH，##STR3##其中R.sup.3和R.sup.4相同或不同，为H，低烷基，羟基，低烷氧基或芳基，R.sup.3和R.sup.4中至少有一个不是羟基和低烷氧基；p为1至5；R.sup.1为H或低烷基；q为1至12；R.sup.2为H，低烷基，低烯基，低炔基，芳基或芳基烷基。这些化合物是心血管药物，例如，在治疗血栓性疾病中有用。
• 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04654357A1

  公开（公告）日：1987-03-31

  7-Oxabicycloheptane substituted sulfonamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.3 and R.sup.4 are the same or different and are H, lower alkyl or aryl; p is 1 to 4; R.sup.1 is H or lower alkyl; and R.sup.2 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了7-Oxabicycloheptane取代磺酰胺前列腺素类似物，其结构式为##STR1##其中m为0至4；A为--CH.dbd.CH--或--CH.sub.2--CH.sub.2--；n为1至5；Q为--CH.dbd.CH--，--CH.sub.2--，##STR2##或单键；R为CO.sub.2H，CO.sub.2烷基，CO.sub.2碱金属，CO.sub.2多羟基胺盐，--CH.sub.2OH，##STR3##其中R.sup.3和R.sup.4相同或不同，为H，低碳基或芳基；p为1至4；R.sup.1为H或低碳基；R.sup.2为H，低碳基，低烯基，低炔基，芳基，芳基烷基，环烷基或环烷基烷基。这些化合物是心血管制剂，例如在治疗血栓性疾病方面有用。
• 7-oxabicycloheptane substituted thioamide-amide prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04647573A1

  公开（公告）日：1987-03-03

  7-Oxabicycloheptane substituted thioamideamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; and R.sup.2 R.sup.3 are the same or different and are H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy, cycloalkyl or cycloalkylalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了7-Oxabicycloheptane取代硫酰胺酰前列腺素类似物，其结构式为##STR1## 其中m为0至4; A为--CH.dbd.CH--或--CH.sub.2--CH.sub.2--; n为1至5; Q为--CH.dbd.CH--, --CH.sub.2--, ##STR2##或单键; R为CO.sub.2H，CO.sub.2烷基，CO.sub.2碱金属，CO.sub.2多羟胺盐，--CH.sub.2OH，其中R.sup.4和R.sup.5相同或不同，为H，低级烷基，羟基，低级烷氧基或芳基，R.sup.4和R.sup.5中至少有一个不是羟基和低级烷氧基; p为1至4; R.sup.1为H或低级烷基; q为1至12; R.sup.2R.sup.3相同或不同，为H，低级烷基，低级烯基，低级炔基，芳基，芳基烷基，低级烷氧基，芳基烷氧基，环烷基或环烷基烷基。这些化合物是心血管药物，例如在治疗血栓性疾病方面有用。
• 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04654356A1

  公开（公告）日：1987-03-31

  7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 and R.sup.3 are the same or different and are H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy or cycloalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  本发明提供了7-Oxabicycloheptane取代二酸二酰胺前列腺素类似物，其结构式为##STR1## 其中m为0至4；A为--CH.dbd.CH--或--CH.sub.2 --CH.sub.2 --；n为1至5；Q为--CH.dbd.CH--，--CH.sub.2 --，##STR2##或单键；R为CO.sub.2 H，CO.sub.2烷基，CO.sub.2碱金属，CO.sub.2多羟胺盐，--CH.sub.2 OH，##STR3##其中R.sup.4和R.sup.5相同或不同，分别为氢、低碳基、羟基、低烷氧基或芳基，R.sup.4和R.sup.5中至少有一个不是羟基和低烷氧基；p为1至4；R.sup.1为氢或低碳基；q为1至12；R.sup.2和R.sup.3相同或不同，分别为氢、低碳基、低烯基、低炔基、芳基、芳基烷基、低烷氧基、芳基氧基或环烷基。这些化合物是心血管药物，在治疗血栓性疾病等方面有用。
• Bicycloheptane substituted diamide and its congener prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04734424A1

  公开（公告）日：1988-03-29

  Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-, aryl-S-, arylalkyl-S-, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  本发明提供了结构式 ##STR1## 的双环庚烷取代酰胺前列腺素类似物，其中m为0至4；A为--CH.dbd.CH--或--CH.sub.2 --CH.sub.2 --；n为1至5；Q为--CH.dbd.CH--、--CH.sub.2 --、##STR2##或单键；R为CO.sub.2 H、CO.sub.2烷基、CO.sub.2碱金属、CO.sub.2多羟基胺盐、--CH.sub.2 OH、##STR3##其中R.sup.4和R.sup.5相同或不同，为H、低碳基、羟基、低烷氧基或芳基，R.sup.4和R.sup.5中至少一个不是羟基和低烷氧基；p为1至4；R.sup.1为H或低碳基；q为1至12；R.sup.2为H或低碳基；R.sup.3为H、低碳基、低烯基、低炔基、芳基、芳基烷基、低烷氧基、芳氧基、芳基烷氧基、氨基、烷基氨基、芳基氨基、芳基烷基氨基、低烷氧基烷基、芳氧基烷基或芳基烷氧基烷基。这些化合物是心血管药物，例如在治疗血栓性疾病方面有用。