XIAP antagonist 1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: XIAP antagonist 1
• 英文别名: methyl 3-[[2-(4-benzylpiperazin-1-yl)acetyl]amino]-5-chloro-1H-indole-2-carboxylate
• 化学式: C₂₃H₂₅ClN₄O₃
• 分子量: 440.9
• InChiKey: FYKQLIUBDQREND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF DIFFERENTIATION AND/OR APOPTOSIS OF PREMALIGNANT AND MALIGNANT CELLS, THEREBY RESTORING THEIR NORMAL-LIKE PHENOTYPE
  申请人：Carmel-Haifa University Economic Corporation Ltd.

  公开号：EP3371173A1

  公开（公告）日：2018-09-12
• [EN] APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF DIFFERENTIATION AND/OR APOPTOSIS OF PREMALIGNANT AND MALIGNANT CELLS, THEREBY RESTORING THEIR NORMAL-LIKE PHENOTYPE<br/>[FR] COMPOSÉS MIMÉTIQUES DE PROTÉINE LIÉE À L'APOPTOSE DANS LA VOIE DE SIGNALISATION DE TGF-BETA (ARTS), COMPOSITIONS, MÉTHODES ET UTILISATIONS CORRESPONDANTS DANS L'INDUCTION DE LA DIFFÉRENTIATION ET/OU DE L'APOPTOSE DE CELLULES PRÉCANCÉREUSES ET MALIGNES, RÉTABLISSANT AINSI LEUR PHÉNOTYPE DE TYPE NORMAL
  申请人：CARMEL-HAIFA UNIV ECONOMIC CORP LTD

  公开号：WO2017077535A1

  公开（公告）日：2017-05-11

  The present invention provides ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Moreover, the novel ARTS mimetic compounds of the invention induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. The invention thus provides compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.