methyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate | 1075217-13-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate
• 英文别名: methyl 1-(prop-2-ynyl) cyclopentanecarboxylate；Methyl 1-(prop-2-yn-1-yl)cyclopentane-1-carboxylate；methyl 1-prop-2-ynylcyclopentane-1-carboxylate
• CAS: 1075217-13-8
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: BAAVOECYIVYZLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 12.0h， 生成 (1-(prop-2-yn-1-yl)cyclopentyl)methanol
  参考文献：
  名称：

  A silver-promoted auto-tandem catalysis for the synthesis of multiply substituted tetrahydrocarbazoles

  摘要：

  三氟甲磺酸银高效催化炔烃醛与吲哚的串联反应，以高产率生成高度取代的四氢咔唑。

  DOI：

  10.1039/c0cc04383d
• 作为产物：
  描述：

  环戊烷甲酸甲酯 、 3-溴丙炔 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.5h， 生成 methyl 1-(prop-2-yn-1-yl)cyclopentanecarboxylate
  参考文献：
  名称：

  在温热条件下，通过复杂的级联反应，由氯代硫酸盐合成磺酸盐。

  摘要：

  氯硫酸盐衍生物是令人感兴趣的试剂，传统上已用于通过氯原子的形式亲核取代获得其他含硫化合物。这项工作描述了含炔的氯代硫酸盐得到磺内酯（内酯的硫类似物）的不同反应方式。在这种转化过程中观察到的复杂骨架重排与有机金属化合物促进或催化的复杂过程相当。然而，这里描述的反应不需要任何试剂或添加剂，仅是热处理。计算计算支持一种基于一系列级联反应的机制，其中几乎每个步骤都是违反直觉的。其中一些步骤包括与经典反应相关的原始过程，

  DOI：

  10.1002/chem.201903228

文献信息

• [EN] PROTEIN KINASE C AGONISTS<br/>[FR] AGONISTES DE PROTÉINE KINASE C
  申请人：GILEAD SCIENCES INC

  公开号：WO2020176505A1

  公开（公告）日：2020-09-03

  The present disclosure relates generally to certain diacylglycerol lactone compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by protein kinase C (PKC) agonists, such as HIV.

  本公开涉及某些二酰基甘油内酯化合物，包括该化合物的药物组合物，以及制备和使用该化合物和药物组合物的方法。本文所披露的化合物和组合物可用于治疗或预防可通过蛋白激酶C（PKC）激动剂调节的疾病、疾病或感染，如艾滋病。
• Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme
  申请人：Liu Gang

  公开号：US20080293713A1

  公开（公告）日：2008-11-27

  The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT- 1 related diseases or conditions are also disclosed.

  本发明涉及式(I)的化合物，其中R1、R2和R3在此定义。还公开了治疗DGAT-1相关疾病或病状的药物组合物和方法。
• INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME
  申请人：Liu Gang

  公开号：US20120041003A1

  公开（公告）日：2012-02-16

  The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

  本发明涉及式(I)的化合物：其中R1，R2和R3在此定义。还公开了治疗DGAT-1相关疾病或病状的药物组合物和方法。
• Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
  申请人：Abbott Laboratories

  公开号：EP2500347A1

  公开（公告）日：2012-09-19

  The present invention relates to compounds of formula (I): wherein R1, R2, and R3, are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

  本发明涉及式（I）化合物：其中 R1、R2 和 R3 在此定义。还公开了治疗 DGAT-1 相关疾病或病症的药物组合物和方法。
• Au(I)-Catalyzed Cascade Reaction Involving Formal Double Hydroamination of Alkynes Bearing Tethered Carboxylic Groups: An Easy Access to Fused Dihydrobenzimidazoles and Tetrahydroquinazolines
  作者：Nitin T. Patil、Anil Kumar Mutyala、Pediredla G. V. V. Lakshmi、Balakrishna Gajula、Balasubramanian Sridhar、Gurava Reddy Pottireddygari、Tadikamalla Prabhakar Rao

  DOI：10.1021/jo1013228

  日期：2010.9.3

  A process involving gold(I)-catalyzed formal double hydroamination of alkynes, bearing a tethered carboxylic group, for the synthesis of fused dihydrobenzimidazoles and tetrahydroquinazolines has been developed. A series of transition metal catalysts have been screened for this transformation, and a catalyst system consisting of Ph3PAuCl (1 mol %) and AgOTf (1 mol %) was found to be the best. The procedure entails the reaction of easily accessible starting materials such as alkynoic acids and 1,2-diaminobenzenes/2-aminobenzylamines in the presence of the catalyst in 1,2-dichloroethane at 100 degrees C. In the case of alpha-substituted alkynoic acids, the corresponding products were obtained in high diastereoselectivities; the structure of the diastereomers has been unambiguously characterized by NMR techniques. The mechanism of the reaction is discussed, and the origin of the diastereoselectivities is addressed. It was observed that under the microwave irradiation conditions, the reaction time is significantly shortened (0.5 h).