2-(2,3-Dihydroindol-1-yl)-2-phenoxyacetaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(2,3-Dihydroindol-1-yl)-2-phenoxyacetaldehyde
• 英文别名: 2-(2,3-dihydroindol-1-yl)-2-phenoxyacetaldehyde
• 化学式: C₁₆H₁₅NO₂
• 分子量: 253.29
• InChiKey: NTYHLLZSPLGVLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Compounds that enhance Atoh-1 expression
  申请人：MASSACHUSETTS EYE & EAR INFIRMARY

  公开号：EP2732819A2

  公开（公告）日：2014-05-21

  This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g. a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

  本发明一般提供化合物、药物组合物及其使用方法，其中包括导致生物细胞中 Atoh1 基因（如 Hath1）表达增加的方法。更具体地说，本发明涉及可从 Atoh1 表达增加中获益的疾病和/或失调症的治疗，例如与听觉毛细胞丧失有关的听力损伤或失调症，或与细胞异常增殖有关的失调症。
• METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP2892523A1

  公开（公告）日：2015-07-15
• EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP3212773A1

  公开（公告）日：2017-09-06
• TREATMENT OF HEARING LOSS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP3743057A1

  公开（公告）日：2020-12-02
• [EN] METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA RÉGÉNÉRATION DE CELLULES CAPILLAIRES ET/OU DE CELLULES AUXILIAIRES
  申请人：MASSACHUSETTS EYE & EAR INFIRM

  公开号：WO2014039908A1

  公开（公告）日：2014-03-13

  Provided are methods and compositions for inducing cells of the inner ear (for example, cochlear and utricular hair cells) to reenter to cell cycle and to proliferate. More particularly, the invention relates to the use of agents that increase c-myc activity and/or Notch activity for inducing cell cycle reentry and proliferation of cochlear or utricular hair cells and/or cochlear or utricular supporting cells. The methods and compositions can be used to promote the proliferation of hair cells and/or supporting cells to treat a subject at risk of, or affected with, hearing loss or a subject at risk of, or affected with vestibular dysfunction.