Disclosed herein a novel, process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline [(S)-1]. Particularly, the invention relates to the synthesis of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline with excellent selectivity starting from commercially available enantiopure (R)-epichlorohydrin [(R)-2] via formation of aziridine intermediate [(S)-4].
本文披露了一种新型的制备(S)-2-乙基-N-(1-甲氧基
丙烷-2-基)-6-甲基
苯胺[(S)-1]的工艺。特别地,本发明涉及从商业上可得到的对映纯(R)-
环氧氯丙烷[(R)-2]出发,通过形成环氧
丙烷中间体[(S)-4]实现(S)-2-乙基-N-(1-甲氧基
丙烷-2-基)-6-甲基
苯胺的合成,具有优异的选择性。