3-Hydroxy-2-(hydroxymethyl)-6-methoxy-6-oxohexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-Hydroxy-2-(hydroxymethyl)-6-methoxy-6-oxohexanoic acid
• 英文别名: 3-hydroxy-2-(hydroxymethyl)-6-methoxy-6-oxohexanoic acid
• 化学式: C₈H₁₄O₆
• 分子量: 206.19
• InChiKey: IXIHMPYPKLWUIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Sequestration of carbon dioxide with hydrogen to useful products
  申请人：UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：US10227617B2

  公开（公告）日：2019-03-12

  Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.

  本文提供的基因工程微生物至少包括碳固定途径的一部分，在一个实施方案中，利用分子氢驱动二氧化碳固定。在一个实施方案中，经过改造的基因工程微生物可将乙酰 CoA、分子氢和二氧化碳转化为 3-羟基丙酸、4-羟基丁酸、乙酰 CoA 或它们的组合，其转化水平高于对照微生物。还可产生其他产物。本文还提供了将乙酰 CoA、分子氢和二氧化碳转化为 3-羟基丙酸酯、4-羟基丁酸酯、乙酰 CoA 或其组合的无细胞组合物。本文还提供了使用转基因微生物和无细胞组合物的方法。
• BIOBASED PRODUCTION OF FUNCTIONALIZED ALPHA-SUBSTITUTED ACRYLATES AND C4-DICARBOXYLATES
  申请人：BioAmber Inc.

  公开号：EP3303375A1

  公开（公告）日：2018-04-11
• SEQUESTRATION OF CARBON DIOXIDE WITH HYDROGEN TO USEFUL PRODUCTS
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US20150211030A1

  公开（公告）日：2015-07-30

  Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.
• US9587256B2
  申请人：——

  公开号：US9587256B2

  公开（公告）日：2017-03-07
• [EN] SEQUESTRATION OF CARBON DIOXIDE WITH HYDROGEN TO USEFUL PRODUCTS<br/>[FR] SÉQUESTRATION DE DIOXYDE DE CARBONE PAR DE L'HYDROGÈNE EN PRODUITS UTILES
  申请人：UNIV NORTH CAROLINA STATE

  公开号：WO2014039879A1

  公开（公告）日：2014-03-13

  Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydoxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4- hydoxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.