19-Oxononadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 19-Oxononadecanoic acid
• 英文别名: 19-oxononadecanoic acid
• 化学式: C₁₉H₃₆O₃
• 分子量: 312.5
• InChiKey: JLQXUMTUWRGNMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  22
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY<br/>[FR] NOUVEAUX LIPIDES CATIONIQUES BIODÉGRADABLES DE FAIBLE MASSE MOLÉCULAIRE À BASE DE DIESTER ET TRIESTER POUR LA DÉLIVRANCE D'OLIGONUCLÉOTIDES
  申请人：MERCK SHARP & DOHME

  公开号：WO2013158579A1

  公开（公告）日：2013-10-24

  The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.

  本发明提供了一种新型的阳离子脂质A公式，可以与胆固醇和PEG脂质等其他脂质成分结合使用，形成含寡核苷酸的脂质纳米粒子。本发明的目的是提供一种阳离子脂质支架，其具有增强的功效，同时由于肝脏中脂质水平降低而具有较低的肝毒性。本发明采用低分子量阳离子脂质，其中一个短脂链与脂链中的可水解功能包括，以增强siRNA在体内传递的效率和耐受性。
• NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY
  申请人：Sirna Therapeutics, Inc.

  公开号：EP2838877A1

  公开（公告）日：2015-02-25
• METHODS AND MATERIALS FOR BIOSYNTHESIZING MULTIFUNCTIONAL, MULTIVARIATE MOLECULES VIA CARBON CHAIN MODIFICATION
  申请人：INVISTA Textiles (U.K.) Limited

  公开号：EP3488000A1

  公开（公告）日：2019-05-29
• [EN] ALBUMIN BINDING CONJUGATE COMPOSITIONS AND METHODS OF MAKING AND USING SAME<br/>[FR] COMPOSITIONS DE CONJUGUÉ DE LIAISON D'ALBUMINE ET PROCÉDÉS DE FABRICATION ET LEUR UTILISATION
  申请人：AMUNIX OPERATING INC

  公开号：WO2017197048A1

  公开（公告）日：2017-11-16

  The present invention concerns compositions of albumin binding conjugates comprising extended recombinant polypeptides (XTEN) with cysteine residues linked to albumin binding subunits with binding affinity to human serum albumin. The invention also provides compositions of albumin binding conjugates comprising therapeutic proteins, therapeutic drugs, or the combination of therapeutic proteins and therapeutic drugs. The invention also provides methods of making and using the albumin binding conjugates compositions.
• [EN] METHODS AND MATERIALS FOR BIOSYNTHESIZING MULTIFUNCTIONAL, MULTIVARIATE MOLECULES VIA CARBON CHAIN MODIFICATION<br/>[FR] PROCÉDÉS ET MATÉRIAUX POUR LA BIOSYNTHÈSE DE MOLÉCULES MULTIFONCTIONNELLES ET MULTIDIMENSIONELLES PAR MODIFICATION DE LA CHAÎNE CARBONÉE
  申请人：INVISTA TEXTILES (U K ) LTD

  公开号：WO2018022633A1

  公开（公告）日：2018-02-01

  This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation, The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.