[6-iodo-2-methyl-4-(2-morpholin-4-ylethyl)-1H-indol-3-yl]-(4-methoxyphenyl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [6-iodo-2-methyl-4-(2-morpholin-4-ylethyl)-1H-indol-3-yl]-(4-methoxyphenyl)methanone
• 化学式: C₂₃H₂₅IN₂O₃
• 分子量: 504.4
• InChiKey: IPKZWQRGOSRNCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] METHODS OF REGULATING CANNABINOID RECEPTOR ACTIVITY-RELATED DISORDERS AND DISEASES<br/>[FR] PROCÉDÉS DE RÉGULATION DE TROUBLES ET MALADIES ASSOCIÉS À UNE ACTIVITÉ DE RÉCEPTEUR CANNABINOÏDE
  申请人：US HEALTH

  公开号：WO2013177418A1

  公开（公告）日：2013-11-28

  This disclosure concerns the discovery of the use of fenoterol analogues for regulating cannabinoid (CB) receptor activity-related disorders and disease, such as dysregulated CB receptors, including treating a disorder or disease, such as a glioblastoma, hepatocellular carcinoma, liver cancer, colon cancer, and/or lung cancer, which is associated with altered cannabinoid receptor activity. In one example, the method includes administering to a subject having or at risk of developing a disorder or disease regulated by CB receptor activity an effective amount of a fenoterol analogue to reduce one or more symptoms associated with the disorder or disease regulated by CB receptor activity.

  本披露涉及发现使用芬特罗类似物来调节与大麻素（CB）受体活性相关的疾病和疾病，如失调的CB受体，包括治疗与改变的大麻素受体活性相关的疾病或疾病，例如胶质母细胞瘤，肝细胞癌，肝癌，结肠癌和/或肺癌。在一个例子中，该方法包括向具有或有发展CB受体活性调节的疾病或疾病的主体施用有效量的芬特罗类似物，以减少与CB受体活性调节的疾病或疾病相关的一个或多个症状。
• METHODS OF REGULATING CANNABINOID RECEPTOR ACTIVITY-RELATED DISORDERS AND DISEASES
  申请人：The United States of America, as represented by The Secretary, Department of Health and Human Services

  公开号：EP2854855A1

  公开（公告）日：2015-04-08
• METHODS OF TREATING BREAST CANCER
  申请人：Mitchell Woods Pharmaceuticals, Inc.

  公开号：EP3125878A2

  公开（公告）日：2017-02-08
• METHODS OF TREATING MELANOMA
  申请人：Mitchell Woods Pharmaceuticals, Inc.

  公开号：EP3125877A2

  公开（公告）日：2017-02-08
• [EN] METHODS OF TREATING BREAST CANCER<br/>[FR] MÉTHODES DE TRAITEMENT DU CANCER DU SEIN
  申请人：MITCHELL WOODS PHARMACEUTICALS INC

  公开号：WO2015153719A2

  公开（公告）日：2015-10-08

  Methods of regulating disorders and diseases in cells expressing β2-adrenergic receptor (AR), cannabinoid (CB) receptor and epidermal growth factor receptor (EGFR), include treating a disorder or disease, such as a breast cancer include administration of a fenoterol analogue.