Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-, sodium salt (1:1)

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-, sodium salt (1:1)
• 英文别名: sodium;8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
• 化学式: C17H11NNaO7+
• 分子量: 364.26
• InChiKey: BQVOPWJSBBMGBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.34
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF
  申请人：Northeastern University

  公开号：US20150099800A1

  公开（公告）日：2015-04-09

  The invention provides for novel lipase inhibitors, and compositions and devices comprising the same. The invention further provides for methods for treatment of disorders comprising administration of novel diacylglycerol lipase inhibitors, and compositions and devices comprising said inhibitors. In some embodiments, the disorders are pancreatitis, obesity, shock or pancreatic necrosis. The invention further provides for novel ether lipid reporter compounds and methods of assaying enzymatic activity comprising contacting a compound with a novel ether lipid reporter compound.

  本发明提供了新型脂肪酶抑制剂，以及包含它们的组合物和装置。本发明还提供了治疗疾病的方法，包括给予新型二酰基甘油脂肪酶抑制剂、含有该抑制剂的组合物和装置。在某些实施例中，这些疾病包括胰腺炎、肥胖症、休克或胰腺坏死。本发明还提供了新型醚脂质报告化合物和测定酶活性的方法，其中将化合物与新型醚脂质报告化合物接触。
• [EN] NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF<br/>[FR] NOUVEAUX INHIBITEURS DE LIPASE, SUBSTRATS RAPPORTEURS ET LEURS UTILISATIONS
  申请人：UNIV NORTHEASTERN

  公开号：WO2013177492A2

  公开（公告）日：2013-11-28

  The invention provides for novel lipase inhibitors, and compositions and devices comprising the same. The invention further provides for methods for treatment of disorders comprising administration of novel diacylglycerol lipase inhibitors, and compositions and devices comprising said inhibitors. In some embodiments, the disorders are pancreatitis, obesity, shock or pancreatic necrosis. The invention further provides for novel ether lipid reporter compounds and methods of assaying enzymatic activity comprising contacting a compound with a novel ether lipid reporter compound.