2-Methoxy-12-methyl-6,11-dioxatetracyclo[7.4.0.03,7.010,12]trideca-1,3(7),4,8-tetraen-13-one | 284679-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-Methoxy-12-methyl-6,11-dioxatetracyclo[7.4.0.03,7.010,12]trideca-1,3(7),4,8-tetraen-13-one
• CAS: 284679-11-4
• 化学式: C₁₃H₁₀O₄
• 分子量: 230.22
• InChiKey: IRCCPIAMCIZXKD-UHFFFAOYSA-N

物化性质

• 沸点：
  377.4±42.0 °C(Predicted)
• 密度：
  1.434±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  52
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Methoxy-12-methyl-6,11-dioxatetracyclo[7.4.0.03,7.010,12]trideca-1,3(7),4,8-tetraen-13-one 450.0~475.0 ℃ 、13.33 Pa 条件下， 以88%的产率得到4-甲氧基-7-甲基吡喃并[3,4-f][1]苯并呋喃-5-酮
  参考文献：
  名称：

  Total synthesis of coriandrin and 7-demethylcoriandrin via a new synthesis of isocoumarins

  摘要：

  Indenone epoxides 8, prepared from the corresponding indenones, have been shown to undergo clean thermal rearrangement to give isocoumarins 10 in high yields. This synthesis of isocoumarins, when applied to oxaindacenone 7, resulted in the total synthesis of coriandrin (1). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00441-x
• 作为产物：
  描述：

  4-Methoxy-6-methylcyclopenta[f][1]benzofuran-5-one 在 双氧水 、 三乙胺 作用下， 以 丙酮 为溶剂， 以40%的产率得到2-Methoxy-12-methyl-6,11-dioxatetracyclo[7.4.0.03,7.010,12]trideca-1,3(7),4,8-tetraen-13-one
  参考文献：
  名称：

  Total synthesis of coriandrin and 7-demethylcoriandrin via a new synthesis of isocoumarins

  摘要：

  Indenone epoxides 8, prepared from the corresponding indenones, have been shown to undergo clean thermal rearrangement to give isocoumarins 10 in high yields. This synthesis of isocoumarins, when applied to oxaindacenone 7, resulted in the total synthesis of coriandrin (1). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00441-x

文献信息

• Total synthesis of coriandrin and 7-demethylcoriandrin via a new synthesis of isocoumarins
  作者：Dipakranjan Mal、Mousumi Bandyopadhyay、Sujit K Ghorai、Kalyani Datta

  DOI：10.1016/s0040-4039(00)00441-x

  日期：2000.5

  Indenone epoxides 8, prepared from the corresponding indenones, have been shown to undergo clean thermal rearrangement to give isocoumarins 10 in high yields. This synthesis of isocoumarins, when applied to oxaindacenone 7, resulted in the total synthesis of coriandrin (1). (C) 2000 Elsevier Science Ltd. All rights reserved.