2-[4-[(E)-C-ethyl-N-(2-indol-1-ylethoxy)carbonimidoyl]phenoxy]-1-(4-methylpiperazin-1-yl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[4-[(E)-C-ethyl-N-(2-indol-1-ylethoxy)carbonimidoyl]phenoxy]-1-(4-methylpiperazin-1-yl)ethanone
• 化学式: C₂₆H₃₂N₄O₃
• 分子量: 448.6
• InChiKey: ZZOHJIGRDZKJSP-SOYKGTTHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  59.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER DISEASES<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE LA DYSLIPIDÉMIE ET D'AUTRES MALADIES
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2014002105A1

  公开（公告）日：2014-01-03

  The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. The present invention is directed towards compounds which can be used to treat diseases such as hyperlipidemia and also have a beneficial effect on cholesterol.

  本发明涉及一般式（I）的化合物，它们的互变异构体，立体异构体，药学上可接受的盐，含有它们的药物组合物，它们的制备方法，这些化合物在医学上的应用以及其制备中涉及的中间体。本发明针对可用于治疗高脂血症等疾病并对胆固醇产生有益影响的化合物。
• COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER DISEASES
  申请人：Cadila Healthcare Limited

  公开号：US20150051144A1

  公开（公告）日：2015-02-19

  The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. The present invention is directed towards compounds which can be used to treat diseases such as hyperlipidemia and also have a beneficial effect on cholesterol.

  本发明涉及一般式(I)的化合物，它们的互变异构体、立体异构体、药学上可接受的盐，含有它们的制药组合物，它们的制备方法，这些化合物在医学上的用途以及它们制备中所涉及的中间体。本发明针对的是可以用于治疗高脂血症等疾病，并且对胆固醇具有有益作用的化合物。