6-methoxypyridine-2,3-diamine dihydrochloride | 94166-62-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-methoxypyridine-2,3-diamine dihydrochloride
• 英文别名: 2,3-diamino-6-methoxy-pyridine dihydrochloride；6-Methoxypyridine-2,3-diamine hydrochloride；6-methoxypyridine-2,3-diamine;hydrochloride
• CAS: 94166-62-8
• 化学式: C₆H₉N₃O*2ClH
• 分子量: 212.079
• InChiKey: YOMVGFCJROPJQP-UHFFFAOYSA-N

物化性质

• 熔点：
  167-171℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.68
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  74.2
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2,3-Diamino-6-methoxypyridine DiHCl
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H302: Harmful if swallowed
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Avoid breathing dust/fume/gas/mist/vapours/spray
P261:
P280: Wear protective gloves/protective clothing/eye protection/face protection
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405: Store locked up

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Section 3. Composition/information on ingredients.
Ingredient name: 2,3-Diamino-6-methoxypyridine DiHCl
CAS number: 94166-62-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels, refrigerated.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C6H9N3O.2ClH
Molecular weight: 212.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  6-methoxypyridine-2,3-diamine dihydrochloride 在 氨 作用下， 以 水 为溶剂， 以92%的产率得到6-甲氧基-2,3-二氨基吡啶盐酸盐
  参考文献：
  名称：

  Process for producing 2,3-diamino-6-methoxypyridine

  摘要：

  本发明涉及一种生产2,3-二氨基-6-甲氧基吡啶的新工艺。该工艺包括中和2,3-二氨基-6-甲氧基吡啶二盐酸盐，而该二盐酸盐是通过还原2-氨基-6-甲氧基-3-硝基吡啶制备而成。2-氨基-6-甲氧基-3-硝基吡啶通过在甲醇中使用甲氧基钠对2-氨基-6-氯-3-硝基吡啶进行甲氧基化而进一步制备。

  公开号：

  US20060080790A1
• 作为产物：
  描述：

  2-氨基-3-硝基-6-甲氧基吡啶 在 盐酸 、 tin(ll) chloride 作用下， 以 水 为溶剂， 反应 6.0h， 以86.4%的产率得到6-methoxypyridine-2,3-diamine dihydrochloride
  参考文献：
  名称：

  Process for producing 2,3-diamino-6-methoxypyridine

  摘要：

  本发明涉及一种生产2,3-二氨基-6-甲氧基吡啶的新工艺。该工艺包括中和2,3-二氨基-6-甲氧基吡啶二盐酸盐，而该二盐酸盐是通过还原2-氨基-6-甲氧基-3-硝基吡啶制备而成。2-氨基-6-甲氧基-3-硝基吡啶通过在甲醇中使用甲氧基钠对2-氨基-6-氯-3-硝基吡啶进行甲氧基化而进一步制备。

  公开号：

  US20060080790A1

文献信息

• Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same
  申请人：Dr. Karl Thomae GmbH

  公开号：US04722929A1

  公开（公告）日：1988-02-02

  The invention relates to novel 2-phenyl-imidazoles of the formula ##STR1## and the tautomers and acid addition salts thereof, particularly the pharmacologically acceptable acid addition salts, which exhibit valuable pharmacological properties, particularly an effect on the contractility of the heart muscle. The compounds of Formula I may be prepared by methods conventionally used for similar compounds.

  本发明涉及新型2-苯基咪唑及其互变异构体和酸加成盐，特别是具有药用价值的酸加成盐，尤其是对心肌收缩力具有显著效果的药物。公式I的化合物可以通过通常用于类似化合物的方法来制备。
• [EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142474A1

  公开（公告）日：2020-07-09

  A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.

  提供了一种制备丙烯酸酯官能化分支有机硅化合物（“化合物”）的方法，包括在催化剂存在下，使（A）分支有机硅化合物和（B）丙烯酸酯化合物发生反应，其中组分（A）具有一般式X-Si（R1）3，其中X包括卤素官能基，每个R1从R和–OSi（R4）3中选择，但至少一个R1为–OSi（R4）3；每个R4从R、–OSi（R5）3和–[OSiR2]mOSiR3中选择；每个R5从R、–OSi（R6）3和–[OSiR2]mOSiR3中选择；每个R6从R和–[OSiR2]mOSiR3中选择；每个R是独立选择的烃基；且0≤m≤100；但至少一个R4、R5和R6为–[OSiR2]mOSiR3。还提供了通过该方法制备的化合物，包括化合物和第二化合物的反应产物的共聚物，形成共聚物的方法，以及包含共聚物的组合物。
• [EN] IMIDAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'IMIDAZOLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013074387A1

  公开（公告）日：2013-05-23

  Disclosed herein are novel imidazole derivative compounds i.e., benzimidazole and aza-benzimidazole derivatives that act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperiipidemia, diabetes mellitus and obesity. Further disclosed are methods of treating various DGAT1 -related diseases, and the use of such imidazole compounds as described herein in the manufacture of a medicament for such treatment.

  本文披露了一种新型咪唑衍生物化合物，即苯并咪唑和氮杂苯并咪唑衍生物，其作为DGAT1抑制剂，并可用于预防、治疗或作为高脂血症、糖尿病和肥胖的治疗药物。进一步披露了治疗各种与DGAT1相关疾病的方法，以及将本文所述的咪唑化合物用于制造用于该治疗的药物的用途。
• [EN] BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142370A1

  公开（公告）日：2020-07-09

  A branched organosilicon compound ("compound") having the general formula (R1)3Si- X-Y is provided. In the formula: each R1 is selected from R and -OSi(R4)3, with the proviso that at least one R1 is -OSi(R4)3; each R is independently a substituted or unsubstituted hydrocarbyl group; each R4 is selected from R, -OSi(R5)3, and -[OSiR2]mOSiR3; each R5 is selected from R, -OSi(R6)3, and -[OSiR2]mOSiR3; each R6 is selected from R and -[OSiR2]mOSiR3; with the proviso that at least one of R4, R5 and R6 is -[OSiR2]mOSiR3; 0

  提供具有一般式（R1）3Si-X-Y的分支有机硅化合物（“化合物”）。在该式中：每个R1从R和-OSi（R4）3中选择，但至少有一个R1为-OSi（R4）3；每个R都是独立的取代或未取代的烃基团；每个R4从R、-OSi（R5）3和-[OSiR2]mOSiR3中选择；每个R5从R、-OSi（R6）3和-[OSiR2]mOSiR3中选择；每个R6从R和-[OSiR2]mOSiR3中选择；但至少有一个R4、R5和R6为-[OSiR2]mOSiR3；0硅烷化反应制备该化合物的方法，包括化合物和与化合物反应的第二化合物的反应产物的共聚物，形成共聚物的方法，以及包括至少一种化合物和共聚物的组合物。
• [EN] BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND RELATED COMPOSITIONS<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ, PROCÉDÉ DE PRÉPARATION CORRESPONDANT ET COMPOSITIONS ASSOCIÉES
  申请人：DOW SILICONES CORP

  公开号：WO2020142380A1

  公开（公告）日：2020-07-09

  A branched organosilicon compound ("compound") having the general formula (R1)3SiX-NR2-D-Z(R7)a is provided. In the formula: each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; where each R4 is selected from R, –OSi(R5)3, and – [OSiR2]mOSiR3; where each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; where each R6 is selected from R and –[OSiR2]mOSiR3; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3; where each R is independently a substituted or unsubstituted hydrocarbyl group; and where 0≤m≤100; each of X and D is an independently selected divalent linking group; each R2 and R7 is an independently selected substituted or unsubstituted hydrocarbyl group or H; Z is O or N; and subscript a is the valency of Z. Also provided is a method of preparing the compound and a composition including the compound.

  提供具有一般式（R1）3SiX-NR2-D-Z（R7）a的分支有机硅化合物（“化合物”）。在公式中：每个R1从R和-OSi（R4）3中选择，条件是至少有一个R1是-OSi（R4）3；其中每个R4从R，-OSi（R5）3和-[OSiR2]mOSiR3中选择；其中每个R5从R，-OSi（R6）3和-[OSiR2]mOSiR3中选择；其中每个R6从R和-[OSiR2]mOSiR3中选择，条件是至少有一个R4，R5和R6是-[OSiR2]mOSiR3；每个R独立地是取代或未取代的烃基；且0≤m≤100；每个X和D是独立选择的二价连接基；每个R2和R7是独立选择的取代或未取代的烃基或H；Z是O或N；下标a是Z的价。还提供了一种制备该化合物的方法和包括该化合物的组合物。