(2-amino-4,5-dimethoxyphenyl)(phenyl)methanol | 1072913-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-amino-4,5-dimethoxyphenyl)(phenyl)methanol
• 英文别名: (2-Amino-4,5-dimethoxyphenyl)-phenylmethanol；(2-amino-4,5-dimethoxyphenyl)-phenylmethanol
• CAS: 1072913-30-4
• 化学式: C₁₅H₁₇NO₃
• 分子量: 259.305
• InChiKey: QUJXDZOONVAPAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-amino-4,5-dimethoxyphenyl)(phenyl)methanol 在 copper(II) choride dihydrate 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2-amino-4,5-dimethoxyphenyl)(phenyl)methanone
  参考文献：
  名称：

  A novel and efficient methodology for the construction of quinazolines based on supported copper oxide nanoparticles

  摘要：

  一系列喹唑啉类化合物通过使用基于负载于高岭土上的氧化铜纳米粒子的新型非均相催化剂，从2-氨基二苯酮和苄胺中合成，产率良好至优异。

  DOI：

  10.1039/c002454f
• 作为产物：
  描述：

  (2-amino-4,5-dimethoxyphenyl)(phenyl)methanone 在 sodium tetrahydroborate 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 生成 (2-amino-4,5-dimethoxyphenyl)(phenyl)methanol
  参考文献：
  名称：

  A Simple Route to Polysubstituted Indoles Exploiting Azide Induced Furan Ring Opening

  摘要：

  A straightforward, efficient indole synthesis based on thermolysis of 2-(2-azidobenzyl)furans with attack of the formed nitrene moiety onto the ipso position of furan ring has been developed. The cyclization is accompanied by furan ring opening and affords indoles with a 2-acylvinyl substituent suitable for further modifications.

  DOI：

  10.1021/ol5018504

文献信息

• A Simple and Efficient Approach to the Synthesis of 2-Phenylquinazolines via sp³ C−H Functionalization
  作者：Jintang Zhang、Dapeng Zhu、Chenmin Yu、Changfeng Wan、Zhiyong Wang

  DOI：10.1021/ol100954x

  日期：2010.6.18

  A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp(3) C-H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.
• Cascade Synthesis of 3-Quinolinecarboxylic Ester via Benzylation/ Propargylation−Cyclization
  作者：Jinmin Fan、Changfeng Wan、Gaojun Sun、Zhiyong Wang

  DOI：10.1021/jo8017654

  日期：2008.11.7

  Reactions of 2-amino-aryl alcohols with beta-ketoesters catalyzed by a catalytic amout of FeCl3 via tandem benzylation-cyclization produce the corresponding 3-quinolinecarboxylic esters in good to high yields. Extending this methodology to propargylation-cyclization, 2-nitrophenyl proparoyl alcohols with beta-ketoesters catalyzed by FeCl3 and SnCl, also produce the 4-alkyne-3-quitiolinecarboxylic esters. The mechanistic details of this benzylation/proparoylation and cyclization cascade process are also discussed.