1-[3-(dimethylamino)propyl]-5-fluoro-3-[(Z)-(5-methoxyindol-3-ylidene)methyl]-3H-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[3-(dimethylamino)propyl]-5-fluoro-3-[(Z)-(5-methoxyindol-3-ylidene)methyl]-3H-indol-2-one
• 化学式: C₂₃H₂₄FN₃O₂
• 分子量: 393.5
• InChiKey: IQSIVANKZLHDRW-RVDMUPIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  45.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Methods and compositions for treating skin to resolve inflammation and screening for actives that stimulate pro-resolution pathways
  申请人：ELC Management LLC

  公开号：US10010492B2

  公开（公告）日：2018-07-03

  Compositions and methods for treating inflamed skin with Pro-Resolution Pathway Stimulators that may be Inflammatory Metabolite Inhibitors, Pro-Resolving Activators, or combinations thereof, and a method for screening active ingredients for activity as Pro-Resolution Pathway Stimulators for incorporation into topical cosmetic products.

  使用可作为炎症代谢物抑制剂、促溶解激活剂或其组合的促溶解途径刺激剂治疗炎症皮肤的组合物和方法，以及筛选活性成分作为促溶解途径刺激剂用于外用化妆品的方法。
• METHOD AND COMPOSITIONS FOR IMPROVING SELECTIVE CATABOLYSIS IN CELLS OF KERATIN SURFACES
  申请人：ELC Management LLC

  公开号：EP2897582A1

  公开（公告）日：2015-07-29
• Methods And Compositions For Treating Skin To Resolve Inflammation And Screening For Actives That Stimulate Pro-Resolution Pathways
  申请人：ELC Management LLC

  公开号：US20170319451A1

  公开（公告）日：2017-11-09

  Compositions and methods for treating inflamed skin with Pro-Resolution Pathway Stimulators that may be Inflammatory Metabolite Inhibitors, Pro-Resolving Activators, or combinations thereof, and a method for screening active ingredients for activity as Pro-Resolution Pathway Stimulators for incorporation into topical cosmetic products.
• [EN] METHOD AND COMPOSITIONS FOR IMPROVING SELECTIVE CATABOLYSIS IN CELLS OF KERATIN SURFACES<br/>[FR] MÉTHODE ET COMPOSITIONS DESTINÉES À AMÉLIORER LE CATABOLISME SÉLECTIF DANS DES CELLULES DE SURFACES KÉRATINIQUES
  申请人：ELC MAN LLC

  公开号：WO2014043009A1

  公开（公告）日：2014-03-20

  A skin care composition for stimulating selective catabolysis in cells of keratin surfaces comprising at least one autophagy activator and at least one proteasome activator, and a method for improving selective catabolysis in cells of keratin surfaces by treating with the composition.