10-Cyclobutyl-1,4,11-triazatricyclo[7.4.1.05,14]tetradeca-5,7,9(14)-triene-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 10-Cyclobutyl-1,4,11-triazatricyclo[7.4.1.05,14]tetradeca-5,7,9(14)-triene-3-carboxylic acid
• 英文别名: 10-cyclobutyl-1,4,11-triazatricyclo[7.4.1.05,14]tetradeca-5,7,9(14)-triene-3-carboxylic acid
• 化学式: C₁₆H₂₁N₃O₂
• 分子量: 287.36
• InChiKey: FUXAMKCABHGHNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  64.6
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• TRICYCLIC QUINOLINE AND QUINOXALINE DERIVATIVES
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：EP2895485A1

  公开（公告）日：2015-07-22
• [EN] TRICYCLIC QUINOLINE AND QUINOXALINE DERIVATIVES<br/>[FR] DÉRIVÉS TRICYCLIQUES DE QUINOLINE ET DE QUINOXALINE
  申请人：ABBVIE DEUTSCHLAND

  公开号：WO2014041131A1

  公开（公告）日：2014-03-20

  The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.