Methyl 2-(acetyloxymethyl)-3-hydroxy-2-methylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Methyl 2-(acetyloxymethyl)-3-hydroxy-2-methylpropanoate
• 英文别名: methyl 2-(acetyloxymethyl)-3-hydroxy-2-methylpropanoate
• 化学式: C₈H₁₄O₅
• 分子量: 190.19
• InChiKey: LXKUMGDTOUCDAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20140301970A1

  公开（公告）日：2014-10-09

  Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.

  制备了包括i) 主要由二价聚乙二醇链组成的中心亲水性块和ii) 两个周边单碳酸酯或多碳酸酯疏水性块的凝胶形成嵌段共聚物。疏水性块包括一个或多个含维生素的亚基。含维生素的亚基包括碳酸酯骨架部分和一个侧链，该侧链包括一种维生素的共价结合形式。这些凝胶形成嵌段共聚物可用于制备各种可生物降解和/或生物相容的水凝胶和有机凝胶药物组合物，特别是抗微生物和/或抗肿瘤药物组合物。水凝胶组合物适用于局部注射。观察到了与包括抗微生物阳离子聚合物和抗微生物化合物的组合物相比，对微生物毒性的协同增强效果。
• BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
  申请人：Cheng Wei

  公开号：US20140080215A1

  公开（公告）日：2014-03-20

  A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n′ greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n′+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L′ is a divalent radical comprising 3 to 30 carbons, and q/(n′+q)×100% equals about 9% to about 47%.
• US9040034B2
  申请人：——

  公开号：US9040034B2

  公开（公告）日：2015-05-26