11-(2,6-Difluoro-3-methoxy-5-propylphenyl)-13-methyl-3-(1-methylpiperidin-4-yl)-4,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,5,7-tetraen-12-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 11-(2,6-Difluoro-3-methoxy-5-propylphenyl)-13-methyl-3-(1-methylpiperidin-4-yl)-4,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,5,7-tetraen-12-one
• 英文别名: 11-(2,6-difluoro-3-methoxy-5-propylphenyl)-13-methyl-3-(1-methylpiperidin-4-yl)-4,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,5,7-tetraen-12-one
• 化学式: C₂₅H₃₀F₂N₆O₂
• 分子量: 484.5
• InChiKey: TZDKHZYJFLJUSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS
  申请人：Incyte Holdings Corporation

  公开号：EP3176170A1

  公开（公告）日：2017-06-07

  The present invention relates to tricyclic compounds of formula (I), and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.

  本发明涉及式（I）的三环化合物及其药物组合物，它们是一种或多种表皮生长因子受体酶的抑制剂，可用于治疗表皮生长因子受体相关疾病，如癌症。
• [EN] SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS<br/>[FR] COMPOSÉS TRICYCLIQUES SUBSTITUÉS UTILISÉS COMME INHIBITEURS DE FGFR
  申请人：INCYTE CORP

  公开号：WO2014007951A2

  公开（公告）日：2014-01-09

  The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.