3-(Tert-butylamino)-1-phenoxybutan-2-ol | 65701-93-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(Tert-butylamino)-1-phenoxybutan-2-ol
• CAS: 65701-93-1
• 化学式: C₁₄H₂₃NO₂
• 分子量: 237.342
• InChiKey: BWOFUFOPJQMSMN-UHFFFAOYSA-N

物化性质

• 沸点：
  358.9±27.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  叔丁胺 、 苯酚 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氟化硼乙醚 作用下， 生成 1-(Tert-butylamino)-3-phenoxybutan-2-ol 、 3-(Tert-butylamino)-1-phenoxybutan-2-ol
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. .alpha.- and .gamma.-Methyl(aryloxy)propanolamines

  摘要：

  A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for beta 1-antagonist action on guinea pig atria and beta 2-antagonist action on guinea pig tracheal strips. Several gamma-methyl(aryloxy)propanolamines showed affinity for beta receptors and a possible preference for beta 2 receptors.

  DOI：

  10.1021/jm00142a017

文献信息

• .beta.-Adrenergic blocking agents. .alpha.- and .gamma.-Methyl(aryloxy)propanolamines
  作者：Thomas L. Lemke、Michael B. Cramer、Stanley W. Adamski、Carolyn A. Pedone、Gary Brooker

  DOI：10.1021/jm00142a017

  日期：1981.10

  A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for beta 1-antagonist action on guinea pig atria and beta 2-antagonist action on guinea pig tracheal strips. Several gamma-methyl(aryloxy)propanolamines showed affinity for beta receptors and a possible preference for beta 2 receptors.