(4aR,7S,8aS)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-7-thiol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: (4aR,7S,8aS)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-7-thiol
• 化学式: C₁₃H₁₆O₃S
• 分子量: 252.334
• InChiKey: BNYFPKWGECETNI-ACJTYDJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL AZABENZIMIDAZOLE TETRAHYDROPYRAN DERIVATIVES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150210685A1

  公开（公告）日：2015-07-30

  Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPKactivated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

  结构式（I）的新化合物是AMP-蛋白激酶的激活剂，可能在治疗、预防和抑制由AMPK激活的蛋白激酶介导的疾病方面有用。本发明的化合物可能在治疗2型糖尿病、高血糖、代谢综合征、肥胖、高胆固醇血症和高血压方面有用。
• NOVEL AZABENZIMIDAZOLE TETRAHYDROPYRAN DERIVATIVES USEFUL AS AMPK ACTIVATORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2888006B1

  公开（公告）日：2019-04-24
• US9382243B2
  申请人：——

  公开号：US9382243B2

  公开（公告）日：2016-07-05
• [EN] NOVEL AZABENZIMIDAZOLE TETRAHYDROPYRAN DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'AZABENZIMIDAZOLE TÉTRAHYDROPYRANE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014031465A1

  公开（公告）日：2014-02-27

  Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPKactivated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.