8-methoxy-3-coumarinoylmethylpyridinium | 772333-74-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8-methoxy-3-coumarinoylmethylpyridinium
• 英文别名: 8-Methoxy-3-(2-pyridin-1-ium-1-ylacetyl)chromen-2-one
• CAS: 772333-74-1
• 化学式: C₁₇H₁₄NO₄
• 分子量: 296.302
• InChiKey: XQUXLQFRDDFVSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-methoxy-3-coumarinoylmethylpyridinium 、 环戊酮 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 以60%的产率得到7-hydroxy-4-methoxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one
  参考文献：
  名称：

  Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin

  摘要：

  Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.03.032

文献信息

• Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin
  作者：G.J. Kharadi

  DOI：10.1016/j.saa.2011.03.032

  日期：2011.9

  Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. (C) 2011 Elsevier B.V. All rights reserved.