4-isothiocyanato-2-chlorobenzoic acid | 486415-44-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-isothiocyanato-2-chlorobenzoic acid
• 英文别名: 2-chloro-4-isothiocyanatobenzoic acid
• CAS: 486415-44-5
• 化学式: C₈H₄ClNO₂S
• 分子量: 213.644
• InChiKey: LCJMEPDBFOJQIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二硫化碳 、 4-氨基-2-氯苯甲酸 在 三乙胺 、 碘 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 26.08h， 生成 4-isothiocyanato-2-chlorobenzoic acid
  参考文献：
  名称：

  EP2248800

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND
  申请人：Takada Junko

  公开号：US20130245305A1

  公开（公告）日：2013-09-19

  The object of the present invention is to provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) by a reaction of the corresponding amino compound having a carboxyl group(s), thiocarbonyldiimidazole and a base, in one step with high purity. An amino compound having a carboxyl group(s) is reacted with thiocarbonyldiimidazole in a solvent in the presence of a base to obtain an isothiocyanate compound having a carboxyl group(s).

  本发明的目的是提供一种新颖的方法，通过在一步中以高纯度反应具有羧基的相应氨基化合物、硫代碳酰二咪唑和碱，来生产具有羧基的异硫氰酸酯化合物。 在溶剂中，将具有羧基的氨基化合物与硫代碳酰二咪唑在碱的存在下反应，以获得具有羧基的异硫氰酸酯化合物。
• Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use
  申请人：——

  公开号：US20030225147A1

  公开（公告）日：2003-12-04

  Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. 1 These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

  氨基噻唑化合物与单取代/双取代苯甲酰胺的结构由式(I)表示，并描述了它们的药学上可接受的盐、药学上可接受的前药、药学上活性代谢物以及所述代谢物的药学上可接受的盐。 这些药物调节和/或抑制细胞增殖和蛋白激酶活性，并可用作治疗恶性肿瘤和其他疾病的药物。
• Method for producing isothiocyanate compound having carboxyl group
  申请人：Nakano Satoshi

  公开号：US08367857B2

  公开（公告）日：2013-02-05

  To provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) from the corresponding amino compound having a carboxyl group(s). A method for producing an isothiocyanate compound which has a carboxyl group(s) and is represented by the formula (2). And the method comprises reacting an amino compound which has a carboxyl group(s) and is represented by the formula (1) (wherein A is e.g. a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group, and B is e.g. a single bond, a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group), in a solvent, with carbon disulfide (CS2) and then with a halogen as a simple substance.

  提供一种从具有羧基的相应氨基化合物中产生具有羧基的异硫氰酸酯化合物的新方法。一种产生具有羧基的异硫氰酸酯化合物的方法，该化合物由公式（2）表示。该方法包括在溶剂中反应具有羧基的氨基化合物，该氨基化合物由公式（1）表示（其中A为例如C6-14芳香烃基或C1-12饱和烃基，B为例如单键，C6-14芳香烃基或C1-12饱和烃基），然后与二硫化碳（CS2）和卤素作为简单物质反应。
• Method for producing isothiocyanate compound
  申请人：Takada Junko

  公开号：US09102602B2

  公开（公告）日：2015-08-11

  The object of the present invention is to provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) by a reaction of the corresponding amino compound having a carboxyl group(s), thiocarbonyldiimidazole and a base, in one step with high purity. An amino compound having a carboxyl group(s) is reacted with thiocarbonyldiimidazole in a solvent in the presence of a base to obtain an isothiocyanate compound having a carboxyl group(s).

  本发明的目的是提供一种新颖的方法，通过一步反应，使用相应的带有羧基的氨基化合物、硫代碳酰二咪唑和碱，高纯度地制备带有羧基的异硫氰酸酯化合物。在溶剂中，在碱的存在下，将带有羧基的氨基化合物与硫代碳酰二咪唑反应，以获得带有羧基的异硫氰酸酯化合物。
• METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND HAVING CARBOXYL GROUP
  申请人：Nakano Satoshi

  公开号：US20100312000A1

  公开（公告）日：2010-12-09

  To provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) from the corresponding amino compound having a carboxyl group(s). A method for producing an isothiocyanate compound which has a carboxyl group(s) and is represented by the formula (2). And the method comprises reacting an amino compound which has a carboxyl group(s) and is represented by the formula (1) (wherein A is e.g. a C 6-14 aromatic hydrocarbon group or a C 1-12 saturated hydrocarbon group, and B is e.g. a single bond, a C 6-14 aromatic hydrocarbon group or a C 1-12 saturated hydrocarbon group), in a solvent, with carbon disulfide (CS2) and then with a halogen as a simple substance.

  提供一种新的方法，用于从具有羧基（s）的相应氨基化合物制备具有羧基（s）的异硫氰酸酯化合物。一种用于生产具有羧基（s）的异硫氰酸酯化合物的方法，其表示为公式（2）。该方法包括在溶剂中反应具有羧基（s）的氨基化合物，其表示为公式（1）（其中A是例如C6-14芳香族碳氢基团或C1-12饱和碳氢基团，B是例如单键，C6-14芳香族碳氢基团或C1-12饱和碳氢基团），与二硫化碳（CS2）然后与卤素作为简单物质。