6-ethyl-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester | 84165-75-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6-ethyl-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester
• 英文别名: 6-Aethyl-7-hydroxy-2-oxo-2H-chromen-3-carbonsaeure-aethylester；Ethyl 6-ethyl-7-hydroxy-2-oxo-2H-chromene-3-carboxylate；ethyl 6-ethyl-7-hydroxy-2-oxochromene-3-carboxylate
• CAS: 84165-75-3
• 化学式: C₁₄H₁₄O₅
• 分子量: 262.262
• InChiKey: RKXZUTJORNJWKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-ethoxycarbonyl-6-chloro-7-hydroxy-8-nitrocoumarin 、 6-ethyl-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 在 3-ethoxycarbonyl-6-ethyl-7-hydroxy-8-nitrocoumarin 作用下， 以to give the title compound 233的产率得到3-ethoxycarbonyl-6-ethyl-7-hydroxy-8-nitrocoumarin
  参考文献：
  名称：

  Coumarin-amide derivatives and its preparation, said drug composition and its use

  摘要：

  本发明涉及新型香豆素衍生物、它们的羧酰胺、包含它们的药物组合物以及它们作为肾脏保护、治疗高血压、心脑血管疾病、非胰岛素依赖性糖尿病、肿瘤、癌前病变和水肿的药物的用途。

  公开号：

  US08338401B2
• 作为产物：
  描述：

  5-ethyl-2,4-dihydroxy-benzaldehyde 、 丙二酸二乙酯 在 哌啶 、 乙醇 作用下， 生成 6-ethyl-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Some New Coumarins and Chromones and their Ultraviolet Absorption Spectra

  摘要：

  DOI：

  10.1021/jo50015a008

文献信息

• Novel coumarin-amide derivatives and its preparation, said drug composition and its use
  申请人：Xu Shiping

  公开号：US20060148834A1

  公开（公告）日：2006-07-06

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.

  本发明涉及新型香豆素衍生物，它们的羧酰胺，包含它们的制药组合物以及它们作为肾脏保护药物、治疗高血压、心脑血管疾病、非胰岛素依赖性糖尿病、肿瘤、癌前病变和水肿的用途。
• THE NOVEL COUMARIN-AMIDE DERIVATIVES AND ITS PREPARATION, SAID DRUG COMPOSITION AND ITS USE
  申请人：THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP1570846A1

  公开（公告）日：2005-09-07

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.

  本发明涉及新型香豆素衍生物、其羧酰胺、含有它们的药物组合物及其作为保护肾脏、治疗高血压、心脑血管疾病、非胰岛素依赖型糖尿病、肿瘤、癌前病变和水肿药物的用途。
• Novel 2H-chromen-2-one-3-carboxamides for medical uses
  申请人：THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP2295053A1

  公开（公告）日：2011-03-16

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them, and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas. Claimed are compounds of general formula (I): wherein R3 is selected from the group consisting , CONHR9 R4 is selected from the group consisting of hydrogen, CONHR10, R5 is selected from the group consisting of H, and C1-C4 alkyl; R6 is selected from the group consisting of H, C1-C12 alkyl, halogen, NO2, and CONHR13, R8 is selected from the group consisting of H, C1-C4 alkyl or alkoxyl, NO2. The other variables are as defined in claims.

  本发明涉及新型香豆素衍生物、它们的羧酰胺、含有它们的药物组合物，以及它们作为保护肾脏的药物、治疗高血压、心脑血管疾病、非胰岛素依赖型糖尿病、肿瘤、癌前病变和水肿的药物的用途。 所要求的是通式(I)化合物： 其中 R3 选自以下组成的组 CONHR9 R4 选自由氢、CONHR10 组成的组 R5 选自由 H 和 C1-C4 烷基组成的组； R6 选自由 H、C1-C12 烷基、卤素、NO2 和 CONHR13 组成的组、 R8选自由H、C1-C4烷基或烷氧基、NO2组成的组。 其他变量如权利要求中所定义。
• An Improved Synthesis of Certain 3-Ethoxycarbonylcoumarins
  作者：Eugene R. Bissell

  DOI：10.1055/s-1982-29968

  日期：——
• BISSELL, E. R., SYNTHESIS, BRD, 1982, N 10, 846-848
  作者：BISSELL, E. R.

  DOI：——

  日期：——