(3S)-3-amino-9-cyclopropyloxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (3S)-3-amino-9-cyclopropyloxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
• 化学式: C₁₈H₁₇N₃O₂
• 分子量: 307.3
• InChiKey: GWCFTDFGFVVPEI-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH INHIBITORS<br/>[FR] COMPOSÉS BIS(FLUOROALKYL) -1,4-BENZODIAZÉPINONES EN TANT QU'INHIBITEURS DE NOTCH
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014047372A1

  公开（公告）日：2014-03-27

  Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein R1 is CH2CH2CF3; R2 is CH2CH2CF3 or CH2CH2CH2CF3; R3 is H, CH3, or Rx; R4 is H or Ry; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.