2-(5-Bromo-7-chloro-2,3-dihydroindol-1-yl)acetaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(5-Bromo-7-chloro-2,3-dihydroindol-1-yl)acetaldehyde
• 英文别名: 2-(5-bromo-7-chloro-2,3-dihydroindol-1-yl)acetaldehyde
• 化学式: C₁₀H₉BrClNO
• 分子量: 274.54
• InChiKey: CCWPCLDVYOMDKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITIORS RELATED APPLICATIONS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2903615A1

  公开（公告）日：2015-08-12
• [EN] INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITIORS RELATED APPLICATIONS<br/>[FR] COMPOSÉS D'INDOLINE UTILISÉS COMME INHIBITEURS DE L'ALDOSTÉRONE SYNTHASE ET APPLICATIONS S'Y RAPPORTANT
  申请人：MERCK SHARP & DOHME

  公开号：WO2014055595A1

  公开（公告）日：2014-04-10

  This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatmen amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.