1-methyl-2,3-dihydro-1H-indene-1-carboxylic acid | 33223-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-methyl-2,3-dihydro-1H-indene-1-carboxylic acid
• 英文别名: 1-methyl-2,3-dihydroindene-1-carboxylic acid
• CAS: 33223-78-8
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: IJYVZCGPRUQYPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-2,3-dihydro-1H-indene-1-carboxylic acid 在 吡啶 、 chromium(VI) oxide 、 lithium aluminium tetrahydride 作用下， 生成 1-methyl-2,3-dihydro-1H-indene-1-carbaldehyde
  参考文献：
  名称：

  Dissymmetric spirans. II. Absolute configuration of 1,1'-spirobiindene and related compounds

  摘要：

  DOI：

  10.1021/ja00785a038
• 作为产物：
  描述：

  1-methyl-3-oxo-indan-1-carboxylic acid 在 氢氧化钾 、 一水合肼 作用下， 以 二乙二醇 为溶剂， 生成 1-methyl-2,3-dihydro-1H-indene-1-carboxylic acid
  参考文献：
  名称：

  Ring size effects in the neophyl rearrangement. VIII. Synthesis and solvolysis of 1-methyl-2,3-benzocycloalkenylcarbinyl tosylates

  摘要：

  DOI：

  10.1021/jo00971a003

文献信息

• [EN] DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS<br/>[FR] INHIBITEURS DOUBLES DE NAV1.2/5HT2A POUR TRAITER DES TROUBLES DU SNC
  申请人：SUNOVION PHARMACEUTICALS INC

  公开号：WO2018026371A1

  公开（公告）日：2018-02-08

  Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

  公开了化学式I的化合物，以及含有这些化合物的药物组合物。还公开了治疗患有神经系统或精神障碍的患者的方法。这些障碍包括抑郁症、躁郁症、疼痛、精神分裂症、强迫症、成瘾、社交障碍、注意力缺陷多动障碍、焦虑障碍、自闭症、认知障碍，或神经精神症状，如冷漠、抑郁、焦虑、精神病、攻击性、激动、冲动控制障碍，以及在神经系统疾病如阿尔茨海默病和帕金森病中的睡眠障碍。
• PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST
  申请人：Tanimoto Koichi

  公开号：US20090258867A1

  公开（公告）日：2009-10-15

  The present invention provides a pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of the following formula [I]: in which R 1 and R 2 are the same or different and each an optionally substituted aryl group etc, R 0 is hydrogen atom, an alkyl group etc, E is a group of the formula: —C(═O)— or —SO 2 —, R is a group of the following formula [i], [ii] or [iii] etc: Ring A is (a) a C 3-8 cycloalkyl group optionally fused to a benzene ring or (b) a benzene ring, Q is a single bond or a methylene group, Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom etc, R 3 is an alkyl group optionally substituted by an alkylthio group, R 4 is hydrogen atom, an alkyl group etc, one of R A and R B is an alkyl group etc, and the other is hydrogen atom, an alkyl group etc, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有CB1受体拮抗活性的吡唑并[1,5-a]嘧啶化合物，其化学式[I]如下：其中，R1和R2相同或不同，分别是可选取代的芳基等；R0是氢原子，烷基等；E是以下式子的基团：—C(═O)—或—SO2—；R是以下式子[i]、[ii]或[iii]等的基团：环A是(a)一个C3-8环烷基，可选地融合到苯环上，或(b)一个苯环；Q是单键或亚甲基基团；环B是一个4-7个成员的脂肪族杂环基团，该环基团通过其环碳原子与相邻的氮原子结合；X是硫原子等；R3是可选取代的烷基，可以是烷基硫基等；R4是氢原子，烷基等；RA和RB中的一个是烷基等，另一个是氢原子，烷基等，或其药学上可接受的盐。
• Chemical Compounds
  申请人：O'Sullivan Anthony Cornelius

  公开号：US20080300285A1

  公开（公告）日：2008-12-04

  The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i), formula (ii), formula (iii) Y is O, S(O) m , NR 3 , CR 5 R 6 , CR 5 R 6 —CR 7 R 8 , O—CR 7 R 8 , S(O) m —CR 7 R 8 , NR 3 —CR 7 R 8 , CR 5 R 6 —O, CR 5 R 6 —S(O) m , CR 5 R 6 —NR 3 , SO 2 —NR 3 , NR 3 —SO 2 , NR 3 —O or O—NR 3 ; m is 0, 1, or 2; the ring (T) formula (T) is a 5- or 6-membered aromatic or heteroaromatic ring; R 1 to R 10 are specified organic groups and n and is 0, 1, 2, 3 or 4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.

  使用式(I)的化合物，其中X为(i)、(ii)或(iii)；式(i)、式(ii)、式(iii)；Y为O、S(O)m、NR3、CR5R6、CR5R6-CR7R8、O-CR7R8、S(O)m-CR7R8、NR3-CR7R8、CR5R6-O、CR5R6-S(O)m、CR5R6-NR3、SO2-NR3、NR3-SO2、NR3-O或O-NR3；m为0、1或2；环(T)的式(T)为5或6元芳香环或杂芳香环；R1至R10为指定的有机基团；n为0、1、2、3或4；或其盐或N-氧化物或含有它们的组合物，用于控制昆虫、螨、线虫或软体动物。同时提供新的化合物。
• Method of combating and controlling insects
  申请人：Syngenta Participations AG

  公开号：US07960310B2

  公开（公告）日：2011-06-14

  The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i), formula (ii), formula (iii) Y is O, S(O)m, NR3, CR5R6, CR5R6—CR7R8, O—CR7R8, S(O)m—CR7R8, NR3—CR7R8, CR5R6—O, CR5R6—S(O)m, CR5R6—NR3, SO2—NR3, NR3—SO2, NR3—O or O—NR3; m is 0, 1, or 2; the ring (T) formula (T) is a 5- or 6-membered aromatic or heteroaromatic ring; R1 to R10 are specified organic groups and n and is 0, 1, 2, 3 or 4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.

  使用公式（I）的化合物，其中X为（i），（ii）或（iii），公式（i），公式（ii），公式（iii）Y为O，S（O）m，NR3，CR5R6，CR5R6-CR7R8，O-CR7R8，S（O）m-CR7R8，NR3-CR7R8，CR5R6-O，CR5R6-S（O）m，CR5R6-NR3，SO2-NR3，NR3-SO2，NR3-O或O-NR3；m为0、1或2；环（T）公式（T）为5-或6-成员芳香或杂芳环；R1至R10为指定的有机基团，n为0、1、2、3或4；或其盐或N-氧化物或含有它们的组合物，用于控制昆虫、螨、线虫或软体动物。同时提供了新的化合物。
• CHEMICAL COMPOUNDS
  申请人：O'Sullivan Anthony Cornelius

  公开号：US20110218341A1

  公开（公告）日：2011-09-08

  The use of a compound of formula I wherein X is (i), (ii) or (iii) Y is O, S(O) m , NR 3 , CR 5 R 6 , CR 5 R 6 —CR 7 R 8 , O—CR 7 R 8 , S(O) m —CR 7 R 8 , NR 3 —CR 7 R 8 , CR 5 R 6 —O, CR 5 R 6 —S(O) m , CR 5 R 6 —NR 3 , SO 2 —NR 3 , NR 3 —SO 2 , NR 3 —O or O—NR 3 ; m is 0, 1, or 2; the ring (T) is a 5- or 6-membered aromatic or heteroaromatic ring; R 1 to R 10 are specified organic groups and n and is 0, 1, 2, 3 or 4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.

  使用公式I的化合物，其中X是(i)、(ii)或(iii)，Y是O、S(O)m、NR3、CR5R6、CR5R6—CR7R8、O—CR7R8、S(O)m—CR7R8、NR3—CR7R8、CR5R6—O、CR5R6—S(O)m、CR5R6—NR3、SO2—NR3、NR3—SO2、NR3—O或O—NR3；m为0、1或2；环(T)是5-或6-成员芳香或杂芳环；R1到R10是指定的有机基团，n为0、1、2、3或4；或其盐或N-氧化物或含有它们的组合物，用于控制昆虫、螨、线虫或软体动物。还提供了新化合物。