(19S)-8-[(dimethylamino)methyl]-19-ethyl-7-hydroxy-19-propan-2-yloxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: (19S)-8-[(dimethylamino)methyl]-19-ethyl-7-hydroxy-19-propan-2-yloxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
• 化学式: C₂₆H₂₉N₃O₅
• 分子量: 463.5
• InChiKey: BQORZRNTAKUYRK-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  92.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

  公开号：US20200347075A1

  公开（公告）日：2020-11-05

  The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

  该披露涉及一种生物活性分子结合物，其制备方法及用途，特别涉及通过改善药物与靶向基团在ADC或SMDC中的偶联而获得的一种新型生物活性分子结合物，以及其制备方法和用于制造用于治疗与异常细胞活性相关的疾病的药物。
• Cytotoxic Conjugates Having Neuropeptide Y Receptor Binding Compound
  申请人：Dong Zheng Xin

  公开号：US20120010154A1

  公开（公告）日：2012-01-12

  There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition states associated with aberrant or undesirable proliferation of cells that express NPY-Y1 receptors.

  提供了一系列新型的神经肽Y-细胞毒性结合物，包括它们的组合物和与它们的治疗用途相关的方法，用于治疗与表达NPY-Y1受体的细胞的异常或不良增殖相关的疾病或病症状态。
• US8709998B2
  申请人：——

  公开号：US8709998B2

  公开（公告）日：2014-04-29
• US8877715B2
  申请人：——

  公开号：US8877715B2

  公开（公告）日：2014-11-04