For-Gly-Gly-DL-Pro-DL-Nle-DL-Phe-NH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: For-Gly-Gly-DL-Pro-DL-Nle-DL-Phe-NH2
• 英文别名: N-[1-[(1-amino-1-oxo-3-phenylpropan-2-yl)amino]-1-oxohexan-2-yl]-1-[2-[(2-formamidoacetyl)amino]acetyl]pyrrolidine-2-carboxamide
• 化学式: C₂₅H₃₆N₆O₆
• 分子量: 516.6
• InChiKey: DJJGYGXMTUUNJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  37
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  180
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES
  申请人：RAMOT AT TEL-AVIV UNIVERSITY LTD.

  公开号：US20140134111A1

  公开（公告）日：2014-05-15

  Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.