2-(2-aminoethyldisulfanyl)ethyl N-methyl-N-[6-[5-(2-phenylphosphanylethylcarbamoyl)-3H-indol-2-yl]naphthalen-2-yl]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(2-aminoethyldisulfanyl)ethyl N-methyl-N-[6-[5-(2-phenylphosphanylethylcarbamoyl)-3H-indol-2-yl]naphthalen-2-yl]carbamate
• 化学式: C₃₃H₃₅N₄O₃PS₂
• 分子量: 630.8
• InChiKey: DRRFMNKSTRFQKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• VARIABLE COLOR TWO-PHOTON FLUORESCENT PROBE, METHOD FOR IMAGING THIOL ACTIVATION IN MITOCHONDRION USING SAME, AND METHOD FOR MANUFACTURING THE VARIABLE COLOR TWO-PHOTON FLUORESCENT PROBE
  申请人：AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20140127737A1

  公开（公告）日：2014-05-08

  The present invention relates to a two-photon fluorescent probe, more particularly a two-photon fluorescent probe represented by Formula 1, a method for preparing same and a method for imaging thiols in mitochondria using same. The two-photon fluorescent probe according to the present invention, having two probes introduced in one molecule, can selectively dye mitochondria and emit intense fluorescence by reacting with thiols. Accordingly, it can be used to image the distribution and activation of thiols in a living cell or an intact living tissue.
• US9005917B2
  申请人：——

  公开号：US9005917B2

  公开（公告）日：2015-04-14