benzyl-(3,4-difluoro-9-methyl-dipyrido[1,2-a;3',4'-d]imidazol-1-yl)-amine | 1207286-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl-(3,4-difluoro-9-methyl-dipyrido[1,2-a;3',4'-d]imidazol-1-yl)-amine
• 英文别名: N-benzyl-3,4-difluoro-10-methyl-1,5,8-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8,10,12-hexaen-6-amine
• CAS: 1207286-71-2
• 化学式: C₁₈H₁₄F₂N₄
• 分子量: 324.333
• InChiKey: DFLLMBWJMPJUHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,3,4-trifluoro-9-methyl-dipyrido[1,2-a;3',4'-d]imidazole 、 苄胺 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 0.5h， 以63%的产率得到benzyl-(3,4-difluoro-9-methyl-dipyrido[1,2-a;3',4'-d]imidazol-1-yl)-amine
  参考文献：
  名称：

  Dipyrido[1,2-a;3′,4′-d]imidazole systems

  摘要：

  Novel tricyclic dipyridoimidazole derivatives can be readily synthesised in one pot processes from various highly fluorinated pyridine systems such as pentafluoropyridine and relatively nucleophilic 2-aminopyridine derivatives. Further nucleophilic aromatic substitution reactions of the novel tricyclic scaffolds allow the regioselective synthesis of various nitrogen, oxygen, carbon and sulfur-functionalised dipyridoimidazole products. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.036

文献信息

• Dipyrido[1,2-a;3′,4′-d]imidazole systems
  作者：Matthew W. Cartwright、Laura Convery、Thomas Kraynck、Graham Sandford、Dmitrii S. Yufit、Judith A.K. Howard、John A. Christopher、David D. Miller

  DOI：10.1016/j.tet.2009.11.036

  日期：2010.1

  Novel tricyclic dipyridoimidazole derivatives can be readily synthesised in one pot processes from various highly fluorinated pyridine systems such as pentafluoropyridine and relatively nucleophilic 2-aminopyridine derivatives. Further nucleophilic aromatic substitution reactions of the novel tricyclic scaffolds allow the regioselective synthesis of various nitrogen, oxygen, carbon and sulfur-functionalised dipyridoimidazole products. (C) 2009 Elsevier Ltd. All rights reserved.