{(5E)-5-[(9-ethyl-9H-carbazol-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: {(5E)-5-[(9-ethyl-9H-carbazol-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
• 英文别名: 2-[(5E)-5-[(9-ethylcarbazol-3-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
• 化学式: C₂₀H₁₆N₂O₃S₂
• 分子量: 396.5
• InChiKey: UJKUWSGQTZRPDK-LICLKQGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability
  申请人：Tanaka Toshio

  公开号：US10227337B2

  公开（公告）日：2019-03-12

  Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).

  提供的是一种评估探针，能够光学评估物质通过中枢神经系统组织的渗透性。同时提供了一种使用中枢神经系统渗透性评估探针评估物质渗透性的评估方法。还提供了一种使用中枢神经系统渗透性评估探针进行筛选的方法。中枢神经系统渗透性评估探针包括至少一种由下列通式（1）表示的化合物作为活性成分。
• Method of inhibiting cancer cell, method for detecting cancer cell, and system for detecting cancer cell
  申请人：CANON KABUSHIKI KAISHA

  公开号：US10220024B2

  公开（公告）日：2019-03-05

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. A cancer cell inhibitory drug containing at least a compound represented by general formula (1).

  本发明的目的是提供一种癌细胞抑制药物，特别是癌干细胞抑制药物或癌干细胞检测探针。一种癌细胞抑制药物至少含有通式（1）代表的化合物。
• EVALUATION PROBE FOR CENTRAL NERVOUS SYSTEM PERMEABILITY, EVALUATION METHOD FOR CENTRAL NERVOUS SYSTEM PERMEABILITY, AND SCREENING METHOD USING AN EVALUATION PROBE FOR CENTRAL NERVOUS SYSTEM PERMEABILITY
  申请人：Tanaka Toshio

  公开号：US20120207683A1

  公开（公告）日：2012-08-16

  Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).
• CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20150274715A1

  公开（公告）日：2015-10-01

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. A cancer cell inhibitory drug containing at least a compound represented by general formula (1).
• METHOD OF INHIBITING CANCER CELL, METHOD FOR DETECTING CANCER CELL, AND SYSTEM FOR DETECTING CANCER CELL
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20170056378A1

  公开（公告）日：2017-03-02

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe.A cancer cell inhibitory drug containing at least a compound represented by general formula (1).