butyl (E)-3-(5-methoxy-2-p-tolylbenzofuran-3-yl)acrylate | 1453187-98-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: butyl (E)-3-(5-methoxy-2-p-tolylbenzofuran-3-yl)acrylate
• 英文别名: butyl (E)-3-[5-methoxy-2-(4-methylphenyl)-1-benzofuran-3-yl]prop-2-enoate
• CAS: 1453187-98-8
• 化学式: C₂₃H₂₄O₄
• 分子量: 364.441
• InChiKey: TWCXVEMBUIBCAG-ACCUITESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以58 mg的产率得到butyl (E)-3-(5-methoxy-2-p-tolylbenzofuran-3-yl)acrylate
  参考文献：
  名称：

  A Practical Protocol for Three-Component, One-Pot, Stepwise Sonogashira-Heterocyclization-Heck Couplings

  摘要：

  A three-component, one-pot, stepwise Sonogashira-heterocyclization-Heck-coupling process was developed starting from either haloarenecarboxamides, halophenols or haloanilines, terminal alkynes and electron-deficient alkenes. Cyclic imidate-, benzofuran-, or indole-type products are obtained, respectively, in useful yields, being typically better than those obtained with isolation of the intermediate Sonogashira adducts. Very high 6-endo selectivity is maintained with imidate-type coupling products despite the presence of copper salts carried over from the Sonogashira coupling.

  DOI：

  10.1055/s-0033-1338873

文献信息

• A Practical Protocol for Three-Component, One-Pot, Stepwise Sonogashira-Heterocyclization-Heck Couplings
  作者：Rosana Alvarez、José Aurrecoechea、Youssef Madich、J. Denis、Aitor Ortega、Claudio Martínez、Abdellatif Matrane、Larbi Belachemi、Angel de Lera

  DOI：10.1055/s-0033-1338873

  日期：——

  A three-component, one-pot, stepwise Sonogashira-heterocyclization-Heck-coupling process was developed starting from either haloarenecarboxamides, halophenols or haloanilines, terminal alkynes and electron-deficient alkenes. Cyclic imidate-, benzofuran-, or indole-type products are obtained, respectively, in useful yields, being typically better than those obtained with isolation of the intermediate Sonogashira adducts. Very high 6-endo selectivity is maintained with imidate-type coupling products despite the presence of copper salts carried over from the Sonogashira coupling.