5-[(2S,3R,4R,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-4-hydroxy-3-methoxyoxolan-2-yl]-1,4-dimethylpyrimidine-2-thione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 5-[(2S,3R,4R,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-4-hydroxy-3-methoxyoxolan-2-yl]-1,4-dimethylpyrimidine-2-thione
• 英文别名: 5-[(2S,3R,4R,5R)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-4-hydroxy-3-methoxyoxolan-2-yl]-1,4-dimethylpyrimidine-2-thione
• 化学式: C₁₆H₂₇N₂O₃PS
• 分子量: 358.4
• InChiKey: WFOWNBMMLYJJEC-APIJFGDWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140148502A1

  公开（公告）日：2014-05-29

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• ENZYMES AND POLYMERASES FOR THE SYNTHESIS OF RNA
  申请人：ModernaTX, Inc.

  公开号：US20170130255A1

  公开（公告）日：2017-05-11

  The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.
• US9790531B2
  申请人：——

  公开号：US9790531B2

  公开（公告）日：2017-10-17