3-[5-(dimethylamino)-4-[(3Z,5Z)-hepta-1,3,5-trien-2-yl]-3-oxo-1,2-dihydropyrrolo[3,4-c]carbazol-6-yl]propanenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[5-(dimethylamino)-4-[(3Z,5Z)-hepta-1,3,5-trien-2-yl]-3-oxo-1,2-dihydropyrrolo[3,4-c]carbazol-6-yl]propanenitrile
• 化学式: C₂₆H₂₆N₄O
• 分子量: 410.5
• InChiKey: ZPLXDXCLLGLODW-FUVGTJSASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] COMPOSITIONS AND METHODS USEFUL IN PREVENTING AND TREATING APICOMPLEXA INFECTIONS<br/>[FR] COMPOSITIONS ET MÉTHODES UTILES POUR LA PRÉVENTION ET LE TRAITEMENT D'INFECTIONS PROVOQUÉES PAR DES PARASITES APICOMPLEXA
  申请人：UNIV PENNSYLVANIA

  公开号：WO2014081922A1

  公开（公告）日：2014-05-30

  The present invention provides compounds that are useful in treating or preventing infection of a mammal by an apicomplexan parasite. The present invention also provides a method of treating infections by an apicomplexan parasite in a mammal, preferably a human. The Apicomplexa are a large group of obligate intracellular protist pathogens, most of which possess a unique organelle called apicoplast and an apical complex structure involved in penetrating a host cell.