1-anilino-3-(1H-indol-2-yl)pyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-anilino-3-(1H-indol-2-yl)pyrrole-2,5-dione
• 化学式: C₁₈H₁₃N₃O₂
• 分子量: 303.3
• InChiKey: YBYWVKMSCYQBMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PROGRANULIN AS MARKER FOR AUTOIMMUNE DISORDERS
  申请人：UNIVERSITAET DES SAARLANDES

  公开号：US20150316548A1

  公开（公告）日：2015-11-05

  The present invention provides for means and method for the detection and/or the quantification of anti-progranulin-autoantibodies in a biological sample of a subject. The present invention also provides for means and method for the detection and/or the quantification of hyper-phosphorylated progranulin in a biological sample of a subject. The present invention further provides for means and methods for the detection of an aberrant conversion pathway of progranulin into granulines in a biological sample of a subject. In fact, the presence of anti-progranulin-autoantibodies and/or hyper-phosphorylated progranulin and/or an aberrant conversion pathway may be indicative that the subject may be suffering from an autoimmune disorder.
• [EN] PROGRANULIN AS MARKER FOR AUTOIMMUNE DISORDERS<br/>[FR] PROGRANULINE EN TANT QUE MARQUEUR POUR DES TROUBLES AUTO-IMMUNS
  申请人：UNIV SAARLAND

  公开号：WO2014083040A2

  公开（公告）日：2014-06-05

  The present invention provides for means and method for the detection and/or the quantification of anti-progranulin-autoantibodies in a biological sample of a subject. The present invention also provides for means and method for the detection and/or the quantification of hyper-phosphorylated progranulin in a biological sample of a subject. The present invention further provides for means and methods for the detection of an aberrant conversion pathway of progranulin into granulines in a biological sample of a subject. In fact, the presence of anti-progranulin-autoantibodies and/or hyper-phosphorylated progranulin and/or an aberrant conversion pathway may be indicative that the subject may be suffering from an autoimmune disorder.