1-(benzyloxymethyl)-cyclopentanopyrimidine-2,4-dione | 160234-23-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(benzyloxymethyl)-cyclopentanopyrimidine-2,4-dione
• 英文别名: 1-(benzyloxymethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-dione；1-(phenylmethoxymethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-dione
• CAS: 160234-23-1
• 化学式: C₁₅H₁₆N₂O₃
• 分子量: 272.304
• InChiKey: ZWMDDHCDBCHDAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(benzyloxymethyl)-cyclopentanopyrimidine-2,4-dione 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以70%的产率得到1-(benzyloxymethyl)-4-thioxocyclopentanopyrimidine-2-one
  参考文献：
  名称：

  Synthesis and Antiviral Study of Cyclopentano [d] Pyrimidine-2,4-diones and Octahydroquinazoline-2,4-diones Acyclic Nucleosides as Potential Anti-HIV Agents

  摘要：

  The Vorbruggen and Niedballa's method((1)) afforded new cycropentano [d] pyrimidine-2,4-dione and octahydroquinazoline-2,4-dione nucleosides. Various modifications of these new derivatives enabled us to obtain HEPT related compounds which were tested against Human Immunodeficiency Virus-1 (HIV-1). Unfortunately, none of these compounds showed significant antiviral activity.

  DOI：

  10.1080/15257779408011863
• 作为产物：
  描述：

  2-ethtylthiocyclopentanopyrimidin-4-one 在 盐酸 、 ammonium sulfate 、 溶剂黄146 、 六甲基二硅氮烷 、 cesium iodide 作用下， 反应 56.0h， 生成 1-(benzyloxymethyl)-cyclopentanopyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and Antiviral Study of Cyclopentano [d] Pyrimidine-2,4-diones and Octahydroquinazoline-2,4-diones Acyclic Nucleosides as Potential Anti-HIV Agents

  摘要：

  The Vorbruggen and Niedballa's method((1)) afforded new cycropentano [d] pyrimidine-2,4-dione and octahydroquinazoline-2,4-dione nucleosides. Various modifications of these new derivatives enabled us to obtain HEPT related compounds which were tested against Human Immunodeficiency Virus-1 (HIV-1). Unfortunately, none of these compounds showed significant antiviral activity.

  DOI：

  10.1080/15257779408011863